M Perreault, A Marette - Nature medicine, 2001 - nature.com Inducible nitric oxide synthase (iNOS) is induced by inflammatory cytokines in
skeletal muscle and fat. It has been proposed that chronic iNOS induction may
cause muscle insulin resistance. Here we show that iNOS expression is ... Cited by 188 - Related articles - BL Direct - All 4 versions
- ►shouxi.net MT Nguyen, H Satoh, S Favelyukis, JL … - Journal of Biological Chemistry, 2005 - ASBMB Lipid infusion and high fat feeding are established causes of systemic and
adipose tissue insulin resistance. In this study, we treated 3T3-L1 adipocytes
with a mixture of free fatty acids (FFAs) to investigate the molecular ... Cited by 150 - Related articles - BL Direct - All 6 versions
- ►case.edu [PDF] L Pirola, AM Johnston, EV Obberghen - Diabetologia, 2004 - Springer Insulin is a key hormone regulating the control of metabolism and the
maintenance of normoglycaemia and normolipidaemia. Insulin acts by binding to
its cell surface receptor, thus activating the receptor's intrinsic ... Cited by 135 - Related articles - BL Direct - All 6 versions
- ►nih.gov JP McClung, CA Roneker, W Mu, DJ Lisk, P … - Proceedings of the National Academy of Sciences, 2004 - National Acad Sciences Insulin resistance, a hallmark of type 2 diabetes, is associated with oxidative
stress. However, the role of reactive oxygen species or specific antioxidant
enzymes in its development has not been tested under physiological ... Cited by 88 - Related articles - BL Direct - All 12 versions
YB Kim, K Kotani, TP Ciaraldi, RR Henry, BB … - Diabetes, 2003 - Am Diabetes Assoc In humans with obesity or type 2 diabetes, insulin target tissues are resistant
to many actions of insulin. The atypical protein kinase C (PKC) isoforms λ and
ζ are downstream of phosphatidylinositol-3 kinase (PI3K) and are required ... Cited by 79 - Related articles - BL Direct - All 5 versions
C Schmitz-Peiffer - ANNALS-NEW YORK ACADEMY OF SCIENCES, 2002 - interscience.wiley.com Abstract: Insulin resistance of skeletal muscle in humans, animals, and cells is
often strongly correlated with increased lipid availability. The elevation of
certain intracellular lipid species can lead to the activation of signal ... Cited by 75 - Related articles - BL Direct - All 5 versions
YB Kim, GI Shulman, BB Kahn - Journal of Biological Chemistry, 2002 - ASBMB To determine the mechanism(s) for insulin resistance induced by fatty acids, we
measured the ability of insulin to activate phosphoinositide 3-kinase (PI3K) and
multiple distal pathways in rats. Following a 5-h infusion of lipid or ... Cited by 62 - Related articles - BL Direct - All 6 versions
- ►endojournals.org F Tremblay, AM Gagnon, A Veilleux, A Sorisky … - Endocrinology, 2005 - Endocrine Soc The mammalian target of rapamycin (mTOR) pathway has recently emerged as a
chronic modulator of insulin-mediated glucose metabolism. In this study, we
evaluated the involvement of this pathway in the acute regulation of ... Cited by 63 - Related articles - All 3 versions
- ►shouxi.net F Tremblay, M Krebs, L Dombrowski, A Brehm, … - Diabetes, 2005 - Am Diabetes Assoc To examine the molecular mechanisms by which plasma amino acid elevation impairs
insulin action, we studied seven healthy men twice in random order during
infusion of an amino acid mixture or saline (total plasma amino acid ∼6 ... Cited by 58 - Related articles - BL Direct - All 5 versions
- ►leptipro.org [PDF] JM Zabolotny, FG Haj, YB Kim, HJ Kim, GI … - Journal of Biological Chemistry, 2004 - ASBMB Previous studies implicate protein-tyrosine phosphatase 1B (PTP1B) and leukocyte
antigen-related phosphatase (LAR) as negative regulators of insulin signaling.
The expression and/or activity of PTP1B and LAR are increased in muscle of ... Cited by 55 - Related articles - BL Direct - All 8 versions
