- ►uoguelph.ca [PDF] MJ Sheetz, GL King - Jama, 2002 - Am Med Assoc Diabetic complications are the major cause of morbidity and mortality in persons
with diabetes. Chronic hyperglycemia is a major initiator of diabetic
microvascular complications (eg, retinopathy, neuropathy, nephropathy). ... Cited by 378 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org A Stitt, TA Gardiner, NL Anderson, P Canning … - Diabetes, 2002 - Am Diabetes Assoc We examined the ability of pyridoxamine (PM), an inhibitor of formation of
advanced glycation end products (AGEs) and lipoxidation end products (ALEs), to
protect against diabetes-induced retinal vascular lesions. The effects of ... Cited by 178 - Related articles - BL Direct - All 6 versions
D Bonnefont-Rousselot - Current Opinion in Clinical Nutrition & Metabolic Care, 2002 - journals.lww.com Purpose of review This review aims at presenting new concepts of glucose-
induced damage in diabetes via an increased production of oxygen free radicals.
Recent findings Reactive oxygen species modulate various biological ... Cited by 132 - Related articles - BL Direct - All 4 versions
RB Caldwell, M Bartoli, MA Behzadian, AEB … - Diabetes/Metabolism Reviews - interscience.wiley.com Retinal neovascularization and macular edema are central features of diabetic
retinopathy, the major cause of blindness in the developed world. Current
treatments are limited in their efficacy and are associated with ... Cited by 90 - Related articles - BL Direct - All 3 versions
- ►pubget.com [PDF] IG Obrosova, AG Minchenko, R Vasupuram, L … - Diabetes, 2003 - Am Diabetes Assoc The study addressed the role for aldose reductase (AR) in 1) retinal oxidative
stress and vascular endothelial growth factor (VEGF) overexpression in early
diabetes, and 2) high glucose-induced oxidative stress in retinal ... Cited by 83 - Related articles - BL Direct - All 5 versions
RA Kowluru, P Koppolu, S Chakrabarti, S … - Free radical research, 2003 - informahealthcare.com Oxidative stress is increased in the retina in diabetes, and long-term
administration of antioxidants inhibits the development of retinopathy in
diabetic rats. The purpose of this study is to determine how diabetes ... Cited by 75 - Related articles - BL Direct - All 8 versions
- ►diabetesjournals.org RA Kowluru, S Odenbach - Diabetes, 2004 - Am Diabetes Assoc Oxidative stress is increased in the retina in diabetes, and it is considered to
play an important role in the development of retinopathy. α-Lipoic acid, a
thiol antioxidant, has been shown to have beneficial effects on ... Cited by 74 - Related articles - BL Direct - All 6 versions
Z Dagher, YS Park, V Asnaghi, T Hoehn, C … - Diabetes, 2004 - Am Diabetes Assoc The polyol (sorbitol) pathway of glucose metabolism is activated in many cell
types when intracellular glucose concentrations are high, and it can generate
cellular stress through several mechanisms. The role of the polyol pathway ... Cited by 65 - Related articles - BL Direct - All 4 versions
RA Kowluru - Diabetes, 2003 - Am Diabetes Assoc Clinical and experimental studies have shown that reinstitution of good glycemic
control (GC) after a period of poor glycemic control (PC) does not produce
immediate benefits on the progression of retinopathy, and hyperglycemia is ... Cited by 61 - Related articles - BL Direct - All 9 versions
- ►iovs.org AJ Barber, DA Antonetti, TS Kern, CEN … - Investigative ophthalmology & visual science, 2005 - ARVO RESULTS. The mean blood glucose of Ins2 Akita mice was significantly elevated,
whereas the body weight at death was reduced compared with that of control
animals. Compared with sibling control mice, the Ins2 Akita mice had ... Cited by 61 - Related articles - All 4 versions
