I Barroso - Diabetic medicine, 2005 - interscience.wiley.com Type 2 diabetes (T2D) has become a health-care problem worldwide, with the rise in disease
prevalence being all the more worrying as it not only affects the developed world but also developing
nations with fewer resources to cope with yet another major disease burden. Furthermore, ... Cited by 101 - Related articles - All 6 versions
- ►rupress.org T Akune, N Ogata, K Hoshi, N Kubota, Y Terauchi, … - Journal of Cell …, 2002 - jcb.rupress.org Insulin receptor substrates (IRS-1 and IRS-2) are essential for intracellular signaling by insulin
and insulin-like growth factor-I (IGF-I), anabolic regulators of bone metabolism. Although mice
lacking the IRS-2 gene (IRS-2 -/- mice) developed normally, they exhibited osteopenia ... Cited by 48 - Related articles - BL Direct - All 8 versions
- ►cell.com ACP Thirone, C Huang, A Klip - Trends in Endocrinology & Metabolism, 2006 - Elsevier In type 2-diabetes and impaired glucose tolerance, the muscle, fat and liver become resistant
to insulin, and recent developments place dysregulation of insulin receptor substrate (IRS) expression
and activation at the center of such defects. IRS1 and IRS2 are the major insulin receptor ... Cited by 42 - Related articles - All 7 versions
N Stefan, P Kovacs, M Stumvoll, RL Hanson, A Lehn- … - Diabetes, 2003 - Am Diabetes Assoc Insulin receptor substrate (IRS)-2 plays an important role in insulin signaling and its disruption
results in diabetes in mice. In humans, the IRS-2 Gly1057Asp substitution was associated with
lower risk of type 2 diabetes in lean individuals, but with a higher risk in obese ... Cited by 37 - Related articles - BL Direct - All 4 versions
M Laakso - Current opinion in lipidology, 2004 - journals.lww.com Recent findings: Common polymorphisms in the PC-1, insulin receptor substrate 1 and 2, and
PPAR-γ2 genes have been linked to insulin resistance and dyslipidaemia, although the results
have not been consistent. However, the Pro12Pro genotype of the PPAR-γ2 gene has ... Cited by 30 - Related articles - BL Direct - All 6 versions
- ►jbc.org AJ McGettrick, EP Feener, CR Kahn - Journal of Biological Chemistry, 2005 - ASBMB The most commonly detected polymorphism in human insulin receptor substrate-1 (IRS-1), a
glycine to arginine change at codon 972 (G972R), is associated with an increased risk of Type
2 diabetes and insulin resistance. To determine the molecular mechanism by which this ... Cited by 21 - Related articles - All 5 versions
- ►endojournals.org R D'Alfonso, MA Marini, L Frittitta, R Sorge, S … - Journal of Clinical …, 2003 - Endocrine Soc We investigated the significance of Gly1057Asp and Leu647Val insulin receptor substrate
(IRS)-2 polymorphisms in two Italian cohorts comprising 186 glucose-tolerant subjects and 240
subjects with type 2 diabetes from the Lazio region (ie representative of central Italy), and ... Cited by 15 - Related articles - BL Direct - All 5 versions
SW Choi, IF Benzie, CS Lam, SWS Chat, J … - Diabetic …, 2005 - interscience.wiley.com Aims The onset of complications in Type 2 diabetes mellitus (DM) patients cannot be predicted
in individuals. Evidence suggests a link between complications and hyperglycaemia, oxidative
stress and antioxidants, but causality is unclear. This study investigated baseline (entry) ... Cited by 8 - Related articles - BL Direct - All 4 versions
D Bodhini, V Radha, R Deepa, S Ghosh, PP … - International Journal of …, 2006 - nature.com The genotype frequency of the IRS-2 G1057D polymorphism was significantly different between
the NGT and type 2 diabetic groups (P=0.0007) in the total study subjects and among the obese
subjects (P=0.00007). Logistic regression analysis showed that the DD genotype showed ... Cited by 7 - Related articles - BL Direct - All 5 versions
K Wagner, K Hemminki, A Försti - Breast Cancer Research and Treatment, 2007 - Springer Abstract The growth hormone 1/insulin-like growth factor-1 (GH1/IGF-1) axis plays an essential
role in the development of the breast by regulating cell prolifer- ation, differentiation and
apoptosis. Imbalances within this axis lead to an aberrant signalling and recent research ... Cited by 6 - Related articles - BL Direct - All 2 versions
