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Scholar Results 1 - 10 of about 47 citing Filipsson: The Neuropeptide Pituitary Adenylate Cyclase–Activating Polypeptide and Islet Function. (0.09 sec) 

PKA-dependent and PKA-independent pathways for cAMP-regulated exocytosis

- physiology.org
S Seino, T Shibasaki - Physiological reviews, 2005 - Am Physiological Soc
Stimulus-secretion coupling is an essential process in secretory cells in which
regulated exocytosis occurs, including neuronal, neuroendocrine, endocrine, and
exocrine cells. While an increase in intracellular Ca 2+ concentration ([Ca ...
Cited by 146 - Related articles - BL Direct - All 4 versions

Inhibitors of dipeptidyl peptidase IV: a novel approach for the prevention and treatment of …


CF Deacon, B Ahrén, JJ Holst - eid, 2004 - informahealthcare.com
Inhibitors of the enzyme dipeptidyl peptidase IV (DPP IV) are of increasing
interest to both diabetologists and the pharmaceutical industry alike, as they
may become established as the next member of the oral antidiabetic class of ...
Cited by 102 - Related articles - All 7 versions

{beta}-Cell Failure in Diabetes and Preservation by Clinical Treatment

- endojournals.org
BL Wajchenberg - Endocrine reviews, 2007 - Endocrine Soc
There is a progressive deterioration in ß-cell function and mass in type 2
diabetics. It was found that islet function was about 50% of normal at the time
of diagnosis, and a reduction in ß-cell mass of about 60% was shown at ...
Cited by 105 - Related articles - BL Direct - All 7 versions

Gut peptides and type 2 diabetes mellitus treatment


B Ahrén - Current Diabetes Reports, 2003 - Springer
Introduction The gut produces and harbors a number of different bio- logical
active peptides. Some of these peptides are true hormones (ie, they are produced
in the gastrointestinal endocrine cells and released into the circulation ...
Cited by 75 - Related articles - BL Direct - All 2 versions

Impaired glucose homeostasis in transgenic mice expressing the human transient neonatal …

- nih.gov
D Ma, JPH Shield, W Dean, I Leclerc, C Knauf, … - Journal of Clinical Investigation, 2004 - Am Soc Clin Investig
Transient neonatal diabetes mellitus (TNDM) is a rare inherited diabetic
syndrome apparent in the first weeks of life and again during early adulthood.
The relative contributions of reduced islet β cell number and impaired β ...
Cited by 59 - Related articles - BL Direct - All 10 versions

PACAP and its receptors exert pleiotropic effects in the nervous system by activating …


CJ Zhou, S Shioda, T Yada, N Inagaki, SJ … - Current Protein and Peptide Science, 2002 - ingentaconnect.com
1 Department of Neurology, University of California, San Francisco, CA
94143-0435; 2 Department of Biology, Waseda University School of Education,
Tokyo 169-8050, Japan; 3 Department of Anatomy, Showa University School of ...
Cited by 51 - Related articles - All 3 versions

Pathways in beta-cell stimulus-secretion coupling as targets for therapeutic insulin …

- diabetesjournals.org
JC Henquin - Diabetes, 2004 - Am Diabetes Assoc
Physiologically, insulin secretion is subject to a dual, hierarchal control by
triggering and amplifying pathways. By closing ATP-sensitive K + channels (K ATP
channels) in the plasma membrane, glucose and other metabolized nutrients ...
Cited by 37 - Related articles - BL Direct - All 4 versions

Overexpression of PACAP in transgenic mouse pancreatic β-cells enhances insulin …


K Yamamoto, H Hashimoto, S Tomimoto, N … - Diabetes, 2003 - Am Diabetes Assoc
Pituitary adenylate cyclase-activating polypeptide (PACAP), a member of the
vasoactive intestinal peptide/secretin/glucagon family, stimulates insulin
secretion from islets in a glucose-dependent manner at femtomolar ...
Cited by 37 - Related articles - BL Direct - All 4 versions

β-Cell-targeted overexpression of phosphodiesterase 3B in mice causes impaired insulin …


L Härndahl, N Wierup, S Enerbäck, H Mulder … - Journal of Biological Chemistry, 2004 - ASBMB
The second messenger cAMP mediates potentiation of glucose-stimulated insulin
release. Use of inhibitors of cAMP-hydrolyzing phosphodiesterase (PDE) 3 and
overexpression of PDE3B in vitro have demonstrated a regulatory role for ...
Cited by 27 - Related articles - BL Direct - All 4 versions

New insights into the central PACAPergic system from the phenotypes in PACAP-and …


H Hashimoto, N Shintani, A Baba - ANNALS-NEW YORK ACADEMY OF SCIENCES, 2006 - interscience.wiley.com
Abstract: Pituitary adenylate cyclase-activating polypeptide (PACAP) is a
structurally highly conserved neuropeptide and displays pleiotropic activity,
including functioning as a neurotransmitter, neuromodulator, and ...
Cited by 24 - Related articles - BL Direct - All 6 versions


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