- ►portlandpress.com C Holm, T Østerlund, H Laurell, JA … - Annual review of nutrition, 2000 - Annual Reviews ▪ Abstract Hormone-sensitive lipase, the rate-limiting enzyme of intracellular TG hydrolysis, is
a major determinant of fatty acid mobilization in adipose tissue as well as other tissues. It plays
a pivotal role in lipid metabolism, overall energy homeostasis, and, presumably, cellular ... Cited by 328 - Related articles - BL Direct - All 15 versions
M Prentki, E Joly, W El-Assaad, R Roduit - Diabetes, 2002 - Am Diabetes Assoc Type 2 diabetes is considered to be in most cases a polygenic disease with a strong involvement
of environmental factors, such as diet and exercise (1). Glucose intolerance in association with
hyperinsulinemia and insulin resistance are early hallmarks of the prediabetic phase ... Cited by 177 - Related articles - BL Direct - All 3 versions
- ►jlr.org FB Kraemer, WJ Shen - The Journal of Lipid Research, 2002 - ASBMB Hormone-sensitive lipase (HSL) is an intracellular neutral lipase that is capable of hydrolyzing
triacylglycerols, diacylglycerols, monoacylglycerols, and cholesteryl esters, as well as other lipid
and water soluble substrates. HSL activity is regulated post-translationally by ... Cited by 116 - Related articles - BL Direct - All 5 versions
GC Yaney, BE Corkey - Diabetologia, 2003 - Springer Increases in glucose or fatty acids affect metabolism via changes in long-chain acyl-CoA formation
and chronically elevated fatty acids increase total cellular CoA. Understanding the response
of pancreatic beta cells to increased amounts of fuel and the role that al- tered insulin ... Cited by 116 - Related articles - BL Direct - All 3 versions
- ►ahajournals.org YH Yu, HN Ginsberg - Circulation research, 2005 - Am Heart Assoc For many years adipose tissue was viewed as the site where excess energy was stored, in the
form of triglycerides (TGs), and where that energy, when needed elsewhere in the body, was
released in the form of fatty acids (FAs). Recently, it has become clear that when the ... Cited by 108 - Related articles - All 7 versions
- ►jbc.org DR Laybutt, A Sharma, DC Sgroi, J Gaudet, S … - Journal of Biological …, 2002 - ASBMB In models of type 2 diabetes the expression of -cell genes is altered, but these changes have
not fully explained the impairment in -cell function. We hypothesized that changes in -cell phenotype
and global alterations in both carbohydrate and lipid pathways are likely to contribute to ... Cited by 98 - Related articles - BL Direct - All 5 versions
SJ Yeaman - Biochemical Journal, 2004 - pubmedcentral.nih.gov Although described initially as an intracellular adipocyte-specific triacylglycerol lipase, it is now
clear that HSL (hormone-sensitive lipase) is expressed in multiple tissues and plays a number
of roles in lipid metabolism, including that of a neutral cholesteryl ester hydrolase. The ... Cited by 99 - Related articles - BL Direct - All 8 versions
- ►diabetesjournals.org R Roduit, C Nolan, C Alarcon, P Moore, A Barbeau, V … - Diabetes, 2004 - Am Diabetes Assoc The malonyl-CoA/long-chain acyl-CoA (LC-CoA) model of glucose-induced insulin secretion
(GIIS) predicts that malonyl-CoA derived from glucose metabolism inhibits fatty acid
oxidation, thereby increasing the availability of LC-CoA for lipid signaling to cellular ... Cited by 89 - Related articles - BL Direct - All 7 versions
- ►jbc.org G Haemmerle, R Zimmermann, JG Strauss, D … - Journal of Biological …, 2002 - ASBMB Hormone-sensitive lipase (HSL) is believed to play an important role in the mobilization of fatty
acids from triglycerides (TG), diglycerides, and cholesteryl esters in various tissues. Because
HSL-mediated lipolysis of TG in adipose tissue (AT) directly feeds non-esterified fatty ... Cited by 79 - Related articles - BL Direct - All 8 versions
EP Haber, HMA Ximenes, J Procopio, … - Journal of cellular …, 2003 - interscience.wiley.com Hyperlipidemia is frequently associated with insulin resistance states as found in type 2 diabetes
and obesity. Effects of free fatty acids (FFA) on pancreatic -cells have long been recognized.
Acute exposure of the pancreatic -cell to FFA results in an increase of insulin release, ... Cited by 75 - Related articles - BL Direct - All 4 versions
