AE Butler, J Janson, S Bonner-Weir, R Ritzel, … - Diabetes, 2003 - Am Diabetes Assoc Type 2 diabetes is characterized by impaired insulin secretion. Some but not all
studies suggest that a decrease in β-cell mass contributes to this. We examined
pancreatic tissue from 124 autopsies: 91 obese cases (BMI >27 kg/m 2 ; 41 ... Cited by 950 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org TA Buchanan, AH Xiang, RK Peters, SL Kjos, … - Diabetes, 2002 - Am Diabetes Assoc Type 2 diabetes frequently results from progressive failure of pancreatic
β-cell function in the presence of chronic insulin resistance. We tested
whether chronic amelioration of insulin resistance would preserve ... Cited by 920 - Related articles - BL Direct - All 6 versions
AH Xiang, RK Peters, SL Kjos, A Marroquin, … - Diabetes, 2006 - Am Diabetes Assoc The Pioglitazone In Prevention Of Diabetes (PIPOD) study was conducted to
evaluate β-cell function, insulin resistance, and the incidence of diabetes
during treatment with pioglitazone in Hispanic women with prior gestational ... Cited by 144 - Related articles - BL Direct - All 13 versions
MY Donath, PA Halban - Diabetologia, 2004 - Springer Increasing evidence indicates that decreased functional beta-cell mass is the
hallmark of both Type 1 and Type 2 diabetes. This underlies the absolute or
relative insu- lin insufficiency in both conditions. In this For Debate, we ... Cited by 122 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org R Basu, E Breda, AL Oberg, CC Powell, C … - Diabetes, 2003 - Am Diabetes Assoc Glucose tolerance decreases with age. For determining the cause of this
decrease, 67 elderly and 21 young (70.1 ± 0.7 vs. 23.7 ± 0.8 years)
participants ingested a mixed meal and received an intravenous injection of ... Cited by 119 - Related articles - BL Direct - All 5 versions
- ►nih.gov F Souza, N Simpson, A Raffo, C Saxena, A … - Journal of Clinical Investigation, 2006 - Am Soc Clin Investig 1 Department of Medicine and 2 Department of Radiology, Columbia University
Medical Center, New York, New York, USA. 3 Institute of Genetics and Biophysics
“Adriano Buzzati-Traverso,” Consiglio Nazionale delle Ricerche, Naples, ... Cited by 45 - Related articles - BL Direct - All 9 versions
PC Butler, JJ Meier, AE Butler, A Bhushan - Nature clinical practice. Endocrinology & metabolism, 2007 - ncbi.nlm.nih.gov Replication of beta cells is an important source of beta-cell expansion in early
childhood. The recent linkage of type 2 diabetes with several transcription
factors involved in cell cycle regulation implies that growth of the ... Cited by 41 - Related articles - BL Direct - All 3 versions
MO Larsen, B Rolin - ILAR JOURNAL., 2004 - dels.nas.edu Animal models of type 1 diabetes remain essential tools for investigation of the
etiology and pathogenesis of the disease and, importantly, for the development
of effective new treatments. Although a range of well-characterized and ... Cited by 38 - Related articles - View as HTML - BL Direct - All 2 versions
- ►diabetesjournals.org AV Matveyenko, PC Butler - Diabetes, 2006 - Am Diabetes Assoc Type 2 diabetes is characterized by defects in insulin secretion and action and
is preceded by impaired fasting glucose (IFG). The islet anatomy in IFG and type
2 diabetes reveals an ∼50 and 65% deficit in β-cell mass, with increased ... Cited by 39 - Related articles - BL Direct - All 4 versions
- ►endojournals.org RA Ritzel, JB Hansen, JD Veldhuis, PC Butler - Journal of Clinical Endocrinology & Metabolism, 2004 - Endocrine Soc In health, most insulin is secreted in pulses. Type 2 diabetes mellitus (TTDM)
is characterized by impaired pulsatile insulin secretion with a defect in
insulin pulse mass. It has been suggested that this defect is partly due to ... Cited by 35 - Related articles - BL Direct - All 5 versions
