- ►harvard.edu [PDF] M Stumvoll, BJ Goldstein, TW van Haeften - The Lancet, 2005 - Elsevier Type 2 diabetes mellitus has become an epidemic, and virtually no physician is without patients
who have the disease. Whereas insulin insensitivity is an early phenomenon partly related to
obesity, pancreas β-cell function declines gradually over time already before the onset of ... Cited by 441 - Related articles - All 17 versions
- ►physiology.org MF White - American Journal of Physiology- Endocrinology And …, 2002 - Am Physiological Soc Although a full understanding of insulin/insulin-like growth factor (IGF) action is evolving, the
discovery of insulin receptor substrate (IRS) proteins and their role to link cell surface receptors
to the intracellular signaling cascades provided an important step forward. Moreover, ... Cited by 391 - Related articles - BL Direct - All 11 versions
- ►endojournals.org HF Escobar-Morreale, M Luque-Ramirez, JL San … - Endocrine …, 2005 - Endocrine Soc The elucidation of the molecular genetic basis of these disorders has been burdened by the
heterogeneity in the diagnostic criteria used to define PCOS, the limited sample size of the studies
conducted to date, and the lack of precision in the identification of ethnic and ... Cited by 128 - Related articles - All 6 versions
- ►diabetesjournals.org K Suzuki, S Hata, Y Kawabata, H Sorimachi - Diabetes, 2004 - Am Diabetes Assoc Variation in the calpain 10 gene has recently been shown to be associated with type 2 diabetes
by positional cloning. Since then, studies on calpain 10 have been started in correlation with
diabetes and insulin-mediated signaling. In this review, the activation mechanism of ... Cited by 106 - Related articles - BL Direct - All 4 versions
- ►nih.gov I Reynisdottir, G Thorleifsson, R Benediktsson, G … - The American Journal of …, 2003 - Elsevier We report a genomewide linkage study of type 2 diabetes (T2D [MIM 125853]) in the Icelandic
population. A list of type 2 diabetics was cross-matched with a computerized genealogical database
clustering 763 type 2 diabetics into 227 families. The diabetic patients and their relatives ... Cited by 97 - Related articles - BL Direct - All 14 versions
- ►endojournals.org SC Elbein, W Chu, Q Ren, C Hemphill, J Schay, … - Journal of Clinical …, 2002 - Endocrine Soc The calpain-10 gene (CAPN10) has been implicated in type 2 diabetes (T2DM) susceptibility
by both linkage and association in a Hispanic population from Starr County Texas. Common
intronic variants seem to alter CAPN10 mRNA levels and were associated with insulin ... Cited by 68 - Related articles - BL Direct - All 6 versions
- ►jbc.org JD Johnson, Z Han, K Otani, H Ye, Y Zhang, H Wu, … - Journal of Biological …, 2004 - ASBMB Cells are programmed to die when critical signaling and metabolic pathways are disrupted. Inhibiting
the type 2 ryanodine receptor (RyR2) in human and mouse pancreatic -cells markedly increased
apoptosis. This mode of programmed cell death was not associated with robust ... Cited by 65 - Related articles - BL Direct - All 5 versions
- ►eje-online.org [PDF] MT Malecki, DK Moczulski, T Klupa, K Wanic, K … - European Journal of …, 2002 - EFES Objective: The polymorphisms of two genes have recently been associated with complex forms
of type 2 diabetes mellitus (T2DM): calpain 10 and peroxisome proliferator-activated
receptor-g (PPARg). Cal- pain 10 is a member of a large family of intracellular proteases. ... Cited by 63 - Related articles - BL Direct - All 9 versions
H Parikh, L Groop - Reviews in Endocrine & Metabolic Disorders, 2004 - Springer About 150 million people suffer from type 2 diabetes in the world today and it has been predicted
that this num- ber will be doubled within 15 years [1]. It is no longer a disease of the elderly, age
at onset has decreased with the epidemic increase in prevalence. There are large eth- nic ... Cited by 62 - Related articles - BL Direct - All 3 versions
- ►oxfordjournals.org DJ Smith, AJ Lusis - Human Molecular Genetics, 2002 - Oxford Univ Press A better understanding of the allelic structure of common human disease loci may help identification
of the responsible genes, and is thus a topic of considerable practical importance. If few alleles
at each locus account for the majority of disease risk, then screening for these causative ... Cited by 62 - Related articles - BL Direct - All 9 versions
