K Yaekura, R Julyan, BL Wicksteed, LB Hays, C … - Journal of Biological …, 2003 - ASBMB Insulin secretory dysfunction of the pancreatic β-cell in type-2 diabetes is thought to be due to
defective nutrient sensing and/or deficiencies in the mechanism of insulin exocytosis. Previous
studies have indicated that the GTP-binding protein, Rab3A, plays a mechanistic role in ... Cited by 58 - Related articles - BL Direct - All 4 versions
MJ Donelan, G Morfini, R Julyan, S Sommers, L … - Journal of Biological …, 2002 - ASBMB The specific biochemical steps required for glucose-regulated insulin exocytosis from -cells are
not well defined. Elevation of glucose leads to increases in cytosolic [Ca 2+ ] i and biphasic release
of insulin from both a readily releasable and a storage pool of -granules. The effect of ... Cited by 48 - Related articles - BL Direct - All 5 versions
- ►nih.gov I Quesada, WC Chin, P Verdugo - Biophysical journal, 2003 - Elsevier InsP 3 is an important link in the intracellular information network. Previous observations show
that activation of InsP 3 -receptor channels on the granular membrane can turn secretory granules
into Ca 2+ oscillators that deliver periodic trains of Ca 2+ release to the cytosol (T. ... Cited by 21 - Related articles - BL Direct - All 8 versions
R Yunes, C Tomes, M Michaut, G De Blas, F Rodriguez … - FEBS letters, 2002 - Elsevier The interaction between Rab3A and calmodulin is necessary for the inhibitory effect of Rab3A
in neuroendocrine cells. Contrastingly, Rab3A triggers the exocytosis known as acrosome reaction
in permeabilized spermatozoa. Here we show that a Rab3A mutant that cannot bind ... Cited by 17 - Related articles - All 5 versions
- ►nutrition.org V Delghingaro-Augusto, F Ferreira, S Bordin, MEC … - Journal of …, 2004 - Am Soc Nutrition Insulin secretion is regulated mainly by circulating nutrients, particularly glucose, and is also
modulated by hormonal and neuronal inputs. Nutritional alterations during fetal and early postnatal
periods, induced by either low protein or energy-restricted diets, produce ß-cell ... Cited by 16 - Related articles - BL Direct - All 5 versions
- ►nih.gov [PDF] JB Park, JS Kim, JY Lee, J Kim, JY Seo, AR … - Biochemical …, 2002 - pubmedcentral.nih.gov Ras-like small GTP-binding proteins of the Rab family regulate trafficking of the secretory or endocytic
pathways. Rab3 proteins within the Rab family are expressed at high levels in neurons and endocrine
cells, where they regulate release of dense-core granules and synaptic vesicles (SVs). ... Cited by 10 - Related articles - BL Direct - All 7 versions
- ►mcponline.org H Lu, Y Yang, EM Allister, N Wijesekara, MB … - Molecular & Cellular …, 2008 - ASBMB Type 2 diabetes (T2D) arises when pancreatic β-cells fail to compensate for systemic insulin
resistance with appropriate insulin secretion. However, the link between insulin resistance and
β-cell failure in T2D is not fully understood. To explore this association, we studied ... Cited by 11 - Related articles - All 7 versions
RS Sidhu, RP Bhullar - Biochemical and Biophysical Research …, 2001 - Elsevier The subcellular distribution of Rab3B in fresh and aged platelets was determined and majority
of the protein was localized with the particulate fraction with only a minor amount detected in
the cytosol. Rab3B was pulled out from platelet particulate fraction with GST–RabGDI-α ... Cited by 5 - Related articles - BL Direct - All 6 versions
K Juhl, J Hutton - Immunology of type 1 diabetes, 2004 - books.google.com CHAPTER 2C Stimulus-Secretion Coupling in the Pancreatic Beta-Cell Kirstine Juhl and John
Hutton Introduction The two most common forms of diabetes in man have very different etiologies
and different clinical presentation. Nevertheless the underlying loss of P-cell function has ... Cited by 2 - Related articles - All 3 versions
SR Lee, AR Kim, JS Kim, J Kim, JY Lee, YL Lee, M … - … and molecular medicine, 2001 - cat.inist.fr Low molecular weight GTP-binding proteins are molecular switches that are believed to play
pivotal roles in cell growth, differentiation, cytoskeletal organization, and vesicular trafficking.
Rab proteins are key playersin the regulation of vesicular transport, while Rho family ... Cited by 2 - Related articles - BL Direct - All 12 versions
