ME Young, PH Guthrie, P Razeghi, B Leighton, S … - Diabetes, 2002 - Am Diabetes Assoc We investigated whether decreased responsiveness of the heart to physiological increases in
fatty acid availability results in lipid accumulation and lipotoxic heart disease. Lean and obese
Zucker rats were either fed ad libitum or fasted overnight. Fasting increased plasma ... Cited by 108 - Related articles - BL Direct - All 5 versions
- ►cardiovascres.org KF Frank, B Bolck, E Erdmann, RHG … - Cardiovascular …, 2003 - cardiovascres.org The cardiac SR Ca 2+ -ATPase (SERCA2a) regulates intracellular Ca 2+ -handling and
thus, plays a crucial role in initiating cardiac contraction and relaxation. SERCA2a may be modulated
through its accessory phosphoprotein phospholamban or by direct phosphorylation ... Cited by 85 - Related articles - All 6 versions
- ►ahajournals.org P Razeghi, ME Young, TC Cockrill, OH Frazier, H … - Circulation, 2002 - Am Heart Assoc Methods and Results— Left ventricular tissue was obtained from nonfailing hearts (n=6) and
from nonischemic failing hearts of patients with or without type 2 diabetes. Myocardial transcript
levels of key regulators in energy substrate metabolism (glucose transporter 1, glucose ... Cited by 65 - Related articles - BL Direct - All 5 versions
KR Bidasee, Y Zhang, CH Shao, M Wang, KP Patel, … - Diabetes, 2004 - Am Diabetes Assoc Prolongation of relaxation is a hallmark of diabetic cardiomyopathy. Most studies attribute this
defect to decreases in sarco(endo)plasmic reticulum Ca 2+ -ATPase (SERCA2a) expression
and SERCA2a-to-phospholamban (PLB) ratio. Since its turnover rate is slow, SERCA2a ... Cited by 59 - Related articles - BL Direct - All 4 versions
- ►physiology.org FL Norby, LE Wold, J Duan, KK Hintz, J … - American Journal of …, 2002 - Am Physiological Soc Diabetic cardiomyopathy is characterized by impaired ventricular contraction and altered function
of insulin-like growth factor I (IGF-I), a key factor for cardiac growth and function. Endogenous
IGF-I has been shown to alleviate diabetic cardiomyopathy. This study was designed to ... Cited by 54 - Related articles - BL Direct - All 7 versions
- ►physiology.org LS Golfman, CR Wilson, S Sharma, M … - American Journal of …, 2005 - Am Physiological Soc It is suggested that insulin resistance and metabolic maladaptation of the heart are causes of
contractile dysfunction. We tested the hypothesis whether systemic PPAR activation, by changing
the metabolic profile in a model of insulin resistance and type 2 diabetes (the ZDF rat) in ... Cited by 51 - Related articles - BL Direct - All 4 versions
- ►fasebj.org [PDF] R Vetter, U Rehfeld, C Reissfelder, W Weiss, KD … - The FASEB Journal, 2002 - FASEB Page 1. The FASEB Journal express article 10.1096/fj.01-1019fje. Published online August
21, 2002. Transgenic overexpression of the sarcoplasmic reticulum Ca 2+ ATPase improves
reticular Ca 2+ handling in normal and diabetic rat hearts ... Cited by 48 - Related articles - BL Direct - All 6 versions
DM Ouwens, C Boer, M Fodor, P De Galan, RJ Heine, … - Diabetologia, 2005 - Springer Abstract Aims/hypothesis: Diabetic cardiomyopathy (DCM) is common in type 2 diabetes. In
DCM, insulin resistance may alter cardiac substrate supply and utilisation leading to changes
in myocardial metabolism and cardiac func- tion. In rats, exposure to excessive alimentary ... Cited by 46 - Related articles - All 4 versions
L Pereira, J Matthes, I Schuster, HH Valdivia, S Herzig, … - Diabetes, 2006 - Am Diabetes Assoc Cardiovascular disease is the leading cause of death in the diabetic population. However, molecular
mechanisms underlying diabetic cardiomyopathy remain unclear. We analyzed Ca 2+ -induced
Ca 2+ release and excitation-contraction coupling in db/db obese type 2 diabetic mice ... Cited by 43 - Related articles - BL Direct - All 6 versions
KR Bidasee, K Nallani, Y Yu, RR Cocklin, Y Zhang, M … - Diabetes, 2003 - Am Diabetes Assoc Decrease in cardiac contractility is a hallmark of chronic diabetes. Previously we showed that
this defect results, at least in part, from a dysfunction of the type 2 ryanodine receptor
calcium-release channel (RyR2). The mechanism(s) underlying RyR2 dysfunction is not ... Cited by 44 - Related articles - BL Direct - All 5 versions
