- ►milray.org [PDF] DA Ehrmann - The New England journal of medicine, 2005 - nejm.highwire.org In 1935, Stein and Leventhal published a paper on their findings in seven women with
amenorrhea, hirsutism, obesity, and a characteristic polycystic appearance to their ovaries —
one of the first descriptions of a complex phenotype today known as the polycystic ovary ... Cited by 503 - Related articles - All 10 versions
- ►endojournals.org HF Escobar-Morreale, M Luque-Ramirez, JL San … - Endocrine …, 2005 - Endocrine Soc The elucidation of the molecular genetic basis of these disorders has been burdened by the
heterogeneity in the diagnostic criteria used to define PCOS, the limited sample size of the studies
conducted to date, and the lack of precision in the identification of ethnic and ... Cited by 128 - Related articles - All 6 versions
S Sam, A Dunaif - Trends in Endocrinology & Metabolism, 2003 - Elsevier Polycystic ovary syndrome (PCOS) is now recognized as an important metabolic and reproductive
disorder. It is associated with substantial defects in insulin action and secretion that confer a
markedly increased risk for type 2 diabetes mellitus. Insulin resistance modifies ... Cited by 95 - Related articles - All 4 versions
RS Legro, JF Strauss… - Fertility and sterility, 2002 - Elsevier Results: The existing literature provides a strong basis for arguing that PCOS clusters in
families. However, the mode of inheritance of the disorder is still uncertain, although the majority
of studies are consistent with an autosomal dominant pattern, modified perhaps by ... Cited by 92 - Related articles - All 11 versions
- ►endojournals.org [PDF] DA Ehrmann, X Tang, I Yoshiuchi, NJ Cox, GI … - Journal of Clinical …, 2002 - Endocrine Soc Insulin resistance is a key component in the pathogenesis of polycystic ovary syndrome
(PCOS) and type 2 diabetes. Poly- morphisms in the genes encoding the insulin receptor
sub- strate (IRS) proteins, IRS-1 (Gly972Arg) and IRS-2 (Gly1057Asp), influence ... Cited by 66 - Related articles - BL Direct - All 6 versions
- ►endojournals.org M Hara, SY Alcoser, A Qaadir, KK Beiswenger, … - Journal of Clinical …, 2002 - Endocrine Soc Twenty-eight of 218 subjects had the Ala allele, all in the heterozygous state. The frequency
of the Ala allele varied among the groups: 0.01 in African-Americans, 0.08 in Caucasians, and
0.15 in Hispanics. Nondiabetic Caucasians with an Ala allele (Pro/Ala group) were more ... Cited by 66 - Related articles - BL Direct - All 6 versions
- ►endojournals.org DA Ehrmann, K Kasza, R Azziz, RS Legro, MN … - Journal of Clinical …, 2005 - Endocrine Soc Racial origin and family history of type 2 diabetes impact upon the risk of developing impaired
glucose tolerance (IGT) and type 2 diabetes, both of which are common in women with polycystic
ovary syndrome (PCOS). We examined the effects of race and family history of type 2 ... Cited by 64 - Related articles - All 8 versions
N Stefan, P Kovacs, M Stumvoll, RL Hanson, A Lehn- … - Diabetes, 2003 - Am Diabetes Assoc Insulin receptor substrate (IRS)-2 plays an important role in insulin signaling and its disruption
results in diabetes in mice. In humans, the IRS-2 Gly1057Asp substitution was associated with
lower risk of type 2 diabetes in lean individuals, but with a higher risk in obese ... Cited by 37 - Related articles - BL Direct - All 4 versions
P Amato, JL Simpson - Best Practice & Research Clinical Obstetrics & …, 2004 - Elsevier Polycystic ovary syndrome (PCOS) is a heterogeneous disorder. There is evidence for a genetic
component in PCOS based on familial clustering of cases. The majority of the evidence supports
an autosomal dominant form of inheritance. Steroidogenesis has been shown to be ... Cited by 36 - Related articles - All 14 versions
- ►free.fr [PDF] C Lautier, SA El Mkadem, E Renard, JF Brun, JC Gris, J … - Human genetics, 2003 - Springer Abstract In order to understand the role of the insulin re- ceptor substrate-2 (IRS2) gene (chromosome
region: 13q34) in obesity, a complex disorder associated with insulin re- sistance and glucose
intolerance, we determined single nu- cleotide polymorphims (SNPs) and complex ... Cited by 29 - Related articles - BL Direct - All 4 versions
