NK Tonks - FEBS letters, 2003 - Elsevier Although initially viewed as housekeeping enzymes, research over the last 15
years has revealed that the protein tyrosine phosphatases (PTPs) are critical
regulators of tyrosine phosphorylation-dependent signaling events and may ... Cited by 144 - Related articles - All 8 versions
- ►fasebj.org JN ANDERSEN, PG JANSEN, SM ECHWALD, … - The FASEB Journal, 2004 - FASEB The protein tyrosine phosphatases (PTPs) are now recognized as critical
regulators of signal transduction under normal and pathophysiological
conditions. In this analysis we have explored the sequence of the human ... Cited by 138 - Related articles - BL Direct - All 9 versions
- ►physiology.org E Asante-Appiah, BP Kennedy - American Journal of Physiology- Endocrinology And …, 2003 - Am Physiological Soc Type 2 diabetes is increasing at an alarming rate worldwide, and there has been
a considerable effort in several laboratories to identify suitable targets for
the design of drugs against the disease. To this end, the protein tyrosine ... Cited by 86 - Related articles - BL Direct - All 3 versions
JL Bento, ND Palmer, JC Mychaleckyj, LA … - Diabetes, 2004 - Am Diabetes Assoc The PTPN1 gene codes for protein tyrosine phosphatase 1B (PTP1B) (EC 3.1.3.48),
which negatively regulates insulin signaling by dephosphorylating the
phosphotyrosine residues of the insulin receptor kinase activation segment. ... Cited by 69 - Related articles - BL Direct - All 6 versions
JM Zabolotny, FG Haj, YB Kim, HJ Kim, GI … - Journal of Biological Chemistry, 2004 - ASBMB Previous studies implicate protein-tyrosine phosphatase 1B (PTP1B) and leukocyte
antigen-related phosphatase (LAR) as negative regulators of insulin signaling.
The expression and/or activity of PTP1B and LAR are increased in muscle of ... Cited by 55 - Related articles - BL Direct - All 8 versions
- ►liptepro.net [PDF] S Zhang, ZY Zhang - Drug discovery today, 2007 - Elsevier Protein tyrosine phosphatase 1B (PTP1B) is an effective target for the treatment
of both type 2 diabetes and obesity; however, targeting PTP1B for drug discovery
is challenging because of the highly conserved and positively charged ... Cited by 51 - Related articles - All 15 versions
ZY Zhang, SY Lee - eid, 2003 - Informa Pharma Science Coordinated tyrosine phosphorylation is essential for signalling pathways
regulated by insulin and leptin. Type 2 diabetes and obesity are character- ised
by resistance to hormones insulin and leptin, possibly due to attenuated or ... Cited by 47 - Related articles - All 4 versions
ND Palmer, JL Bento, JC Mychaleckyj, CD … - DIABETES-NEW YORK-, 2004 - Am Diabetes Assoc Protein tyrosine phosphatase (PTP)-1B, encoded by the PTPN1 gene, catalyzes the
dephosphorylation of pro- teins at tyrosyl residues. PTP-1B has been implicated
in negatively regulating insulin signaling by dephosphory- lating the ... Cited by 45 - Related articles - BL Direct - All 6 versions
O Ukkola, M Santaniemi - Journal of internal medicine, 2002 - interscience.wiley.com It is also possible that your web browser is not configured or not able to
display style sheets. In this case, although the visual presentation will be
degraded, the site should continue to be functional. We recommend using the ... Cited by 42 - Related articles - BL Direct - All 4 versions
T Fukada, NK Tonks - The EMBO Journal, 2003 - pubmedcentral.nih.gov Changes in expression of PTP1B, the prototypic protein tyrosine phosphatase,
have been associated with various human diseases; however, the mechanisms by
which PTP1B expression is regulated have not been defined. We have ... Cited by 37 - Related articles - BL Direct - All 4 versions
