SG Straub, GWG Sharp - Diabetes/Metabolism Reviews - interscience.wiley.com Glucose-stimulated biphasic insulin secretion involves at least two signaling pathways, the KATP
channel-dependent and KATP channel-independent pathways, respectively. In the former, enhanced
glucose metabolism increases the cellular adenosine triphosphate/adenosine ... Cited by 156 - Related articles - BL Direct - All 3 versions
G Bertrand, N Ishiyama, M Nenquin, MA Ravier, JC … - Journal of Biological …, 2002 - ASBMB Glucose increases insulin secretion by raising cytoplasmic Ca 2+ ([Ca 2+ ] i ) in β-cells (triggering
pathway) and augmenting the efficacy of Ca 2+ on exocytosis (amplifying pathway). It has been
suggested that glutamate formed from α-ketoglutarate is a messenger of the amplifying ... Cited by 69 - Related articles - BL Direct - All 5 versions
SG Straub, G Shanmugam, GWG Sharp - Diabetes, 2004 - Am Diabetes Assoc Electron microscopy and quantitative stereological techniques were used to study the dynamics
of the docked granule pool in the rat pancreatic β-cell. The mean number of granules per β-cell
was 11,136. After equilibration in RPMI containing 5.6 mmol/l glucose, 6.4% of the ... Cited by 23 - Related articles - BL Direct - All 5 versions
- ►physiology.org N Ishiyama, MA Ravier, JC Henquin - American Journal of …, 2006 - Am Physiological Soc Glucose induces insulin secretion (IS) and also potentiates the insulin-releasing action of secretagogues
such as arginine and sulfonylureas. This potentiating effect is known to be impaired in type 2
diabetic patients, but its cellular mechanisms are unclear. IS and cytosolic Ca 2+ ... Cited by 11 - Related articles - BL Direct - All 4 versions
- ►endojournals.org S Yamada, M Komatsu, Y Sato, K Yamauchi, I Kojima, … - Endocrinology, 2002 - Endocrine Soc Isolated rat islets were exposed to cAMP-elevating agents and/or nutrients. Insulin exocytosis
subsequently triggered by a depolarizing concentration of K + or a stimulatory concentration
of glucose was employed as an index of time-dependent potentiation (TDP). Stimulatory ... Cited by 11 - Related articles - BL Direct - All 4 versions
NE Simpson, N Khokhlova, JA Oca-Cossio, I … - Diabetologia, 2006 - Springer Page 1. Diabetologia (2006) 49: 1338–1348 DOI 10.1007/s00125-006-0216-5
ARTICLE NE Simpson . N. Khokhlova . JA Oca-Cossio . I. Constantinidis Insights
into the role of anaplerosis in insulin secretion: a 13 C NMR study ... Cited by 11 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org SC Gunawardana, JV Rocheleau, WS Head, DW … - Diabetes, 2006 - Am Diabetes Assoc Time-dependent potentiation (TDP) of insulin release is normally absent in mice. However, we
recently demonstrated that TDP occurs in mouse islets under conditions of forced decrease of
intracellular pH (pH i ) associated with elevated NADPH+H + (NADPH) levels. Hence, ... Cited by 7 - Related articles - BL Direct - All 5 versions
- ►endojournals.org K Nabe, S Fujimoto, M Shimodahira, R Kominato, Y … - Endocrinology, 2006 - Endocrine Soc Diphenylhydantoin (DPH), which is clinically used in the treatment of epilepsy, inhibits
glucose-induced insulin release from pancreatic islets by a mechanism that remains
unknown. In the present study, DPH is shown to suppress glucose-induced insulin ... Cited by 6 - Related articles - BL Direct - All 4 versions
- ►physiology.org SC Gunawardana, YJ Liu, MJ MacDonald, … - American Journal of …, 2004 - Am Physiological Soc Nutrients that induce biphasic insulin release, such as glucose and leucine, provide acetyl-CoA
and anaplerotic input in the -cell. The first phase of release requires increased ATP production
leading to increased intracellular Ca 2+ concentration ([Ca 2+ ] i ). The second phase ... Cited by 5 - Related articles - BL Direct - All 3 versions
U Nakamura, M Iwase, Y Uchizono, K Sonoki, N … - Free Radical Biology and …, 2006 - Elsevier Pancreatic β-cell death induced by oxidative stress plays an important role in the pathogenesis
of diabetes mellitus. We studied the relation between rapid intracellular acidification and cell
death of pancreatic β-cell line NIT-1 cells exposed to H 2 O 2 or alloxan. Intracellular pH ... Cited by 6 - Related articles - All 4 versions
