ER Pearson, BJ Starkey, RJ Powell, FM Gribble, PM … - The Lancet, 2003 - Elsevier Type 2 diabetes shows evidence of underlying heterogeneity. No studies have assessed whether
different causes for diabetes change the response to oral hypoglycaemic therapy. In a few
cases, patients with diabetes caused by mutations in the hepatocyte nuclear factor 1α ... Cited by 133 - Related articles - All 4 versions
- ►nih.gov S Xuan, T Kitamura, J Nakae, K Politi, Y … - Journal of Clinical …, 2002 - Am Soc Clin Investig Defective insulin secretion is a feature of type 2 diabetes that results from inadequate compensatory
increase of β cell mass and impaired glucose-dependent insulin release. β cell proliferation and
secretion are thought to be regulated by signaling through receptor tyrosine kinases. In ... Cited by 117 - Related articles - BL Direct - All 11 versions
- ►cell.com P Steneberg, N Rubins, R Bartoov-Shifman, MD Walker … - Cell metabolism, 2005 - Elsevier Obesity is typically associated with elevated levels of free fatty acids (FFAs) and is linked to glucose
intolerance and type 2 diabetes. FFAs exert divergent effects on insulin secretion from β
cells: acute exposure to FFAs stimulates insulin secretion, whereas chronic exposure ... Cited by 113 - Related articles - All 11 versions
- ►jbc.org A Miura, K Yamagata, M Kakei, H Hatakeyama, N … - Journal of Biological …, 2006 - ASBMB Mutations in the hepatocyte nuclear factor (HNF)-4 gene cause a form of maturity-onset diabetes
of the young (MODY1) that is characterized by impairment of glucose-stimulated insulin secretion
by pancreatic -cells. HNF-4 , a transcription factor belonging to the nuclear receptor ... Cited by 51 - Related articles - BL Direct - All 8 versions
A Stride, M Shepherd, TM Frayling, MP Bulman, S … - Diabetes Care, 2002 - Am Diabetes Assoc OBJECTIVE—In animals, experimentally induced maternal hyperglycemia during pregnancy
results in hyperglycemic offspring. Similarly, Pima Indian offspring with mothers who are diabetic
at the time of pregnancy have increased risk of early-onset diabetes. We hypothesized ... Cited by 42 - Related articles - BL Direct - All 6 versions
- ►endojournals.org [PDF] V Lilla, G Webb, K Rickenbach, A Maturana, DF Steiner … - Endocrinology, 2003 - Endocrine Soc To identify genes involved in regulated insulin secretion, we have established and characterized
two sublines derived from the mouse pancreatic ß-cell line MIN6, designated B1 and C3. They
have a similar insulin content, but differ in their secre- tory properties. B1 responded to ... Cited by 41 - Related articles - BL Direct - All 4 versions
- ►cell.com P Akpinar, S Kuwajima, J Krützfeldt, M Stoffel - Cell Metabolism, 2005 - Elsevier The signals and molecular mechanisms that regulate the replication of terminally differentiated
β cells are unknown. Here, we report the identification and characterization of transmembrane
protein 27 (Tmem27, collectrin) in pancreatic β cells. Expression of Tmem27 is reduced in ... Cited by 40 - Related articles - All 12 versions
- ►ukpmc.ac.uk Y Fujitani, S Fujitani, DF Boyer, M Gannon, Y … - Genes & …, 2006 - genesdev.cshlp.org Pdx1 (IPF-1 in humans, which is altered in MODY-4) is essential for pancreas development and
mature β-cell function. Pdx1 is expressed dynamically within the developing foregut, but how
its expression characteristics are linked to the various steps of organ specification, ... Cited by 37 - Related articles - BL Direct - All 12 versions
- ►cell.com I Konstantinova, G Nikolova, M Ohara-Imaizumi, P … - Cell, 2007 - Elsevier In vertebrates, β cells are aggregated in the form of pancreatic islets. Within these islets, communication
between β cells inhibits basal insulin secretion and enhances glucose-stimulated insulin
secretion, thus contributing to glucose homeostasis during fasting and feeding. In the ... Cited by 35 - Related articles - All 13 versions
- ►oxfordjournals.org C Haumaitre, M Fabre, S Cormier, C … - Human molecular …, 2006 - Oxford Univ Press Heterozygous mutations in the HNF1ß/vHNF1/TCF2 gene cause maturity-onset diabetes of the
young (MODY5), associated with severe renal disease and abnormal genital tract. Here, we
characterize two fetuses, a 27-week male and a 31.5-week female, carrying novel ... Cited by 29 - Related articles - BL Direct - All 6 versions
