RJ Shaw, M Kosmatka, N Bardeesy, RL … - Proceedings of the …, 2004 - National Acad Sciences AMP-activated protein kinase (AMPK) is a highly conserved sensor of cellular energy status found
in all eukaryotic cells. AMPK is activated by stimuli that increase the cellular AMP/ATP ratio. Essential
to activation of AMPK is its phosphorylation at Thr-172 by an upstream kinase, AMPKK, ... Cited by 367 - Related articles - BL Direct - All 9 versions
- ►endojournals.org BJ Goldstein, R Scalia - Journal of Clinical Endocrinology & Metabolism, 2004 - Endocrine Soc Cardiovascular disease accounts for an overwhelming proportion of the morbidity and mortality
suffered by patients with obesity and type 2 diabetes mellitus, and recent work has elucidated
several potential mechanisms by which increased adiposity enhances cardiovascular ... Cited by 329 - Related articles - BL Direct - All 6 versions
- ►nih.gov RR Russell III, J Li, DL Coven, M Pypaert, … - Journal of Clinical …, 2004 - Am Soc Clin Investig AMP-activated protein kinase (AMPK) is an important regulator of diverse cellular pathways in
the setting of energetic stress. Whether AMPK plays a critical role in the metabolic and functional
responses to myocardial ischemia and reperfusion remains uncertain. We examined the ... Cited by 199 - Related articles - BL Direct - All 9 versions
- ►ahajournals.org MC Towler, DG Hardie - Circulation research, 2007 - Am Heart Assoc The AMP-activated protein kinase (AMPK) system acts as a sensor of cellular energy status that
is conserved in all eukaryotic cells. It is activated by increases in the cellular AMP:ATP ratio caused
by metabolic stresses that either interfere with ATP production (eg, deprivation for glucose ... Cited by 164 - Related articles - All 7 versions
- ►diabetesjournals.org P Schrauwen, MKC Hesselink - Diabetes, 2004 - Am Diabetes Assoc Recent evidence points toward decreased oxidative capacity and mitochondrial aberrations
as a major contributor to the development of insulin resistance and type 2 diabetes. In this article
we will provide an integrative view on the interrelation between decreased oxidative ... Cited by 160 - Related articles - BL Direct - All 4 versions
- ►nih.gov [PDF] G da Silva Xavier, I Leclerc, A Varadi, T … - Biochemical …, 2003 - pubmedcentral.nih.gov AMP-activated protein kinase (AMPK) has recently been impli- cated in the control of preproinsulin
gene expression in pancreatic islet β-cells [da Silva Xavier, Leclerc, Salt, Doiron, Hardie, Kahn
and Rutter (2000) Proc. Natl. Acad. Sci. USA 97, 4023–4028]. Using pharmacological and ... Cited by 146 - Related articles - BL Direct - All 9 versions
D Nagata, M Mogi, K Walsh - Journal of Biological Chemistry, 2003 - ASBMB AMP-activated protein kinase (AMPK) is a stress-activated protein kinase that is regulated by
hypoxia and other cellular stresses that result in diminished cellular ATP levels. Here, we investigated
whether AMPK signaling in endothelial cells has a role in regulating angiogenesis. ... Cited by 131 - Related articles - BL Direct - All 4 versions
BD Hegarty, SM Furler, J Ye, GJ Cooney, … - Acta Physiologica …, 2003 - interscience.wiley.com It is also possible that your web browser is not configured or not able to display style sheets.
In this case, although the visual presentation will be degraded, the site should continue to be
functional. We recommend using the latest version of Microsoft or Mozilla web browser to ... Cited by 122 - Related articles - BL Direct - All 4 versions
VA Morrow, F Foufelle, JMC Connell, JR Petrie, GW … - Journal of Biological …, 2003 - ASBMB Recent studies have indicated that endothelial nitric-oxide synthase (eNOS) is regulated by reversible
phosphorylation in intact endothelial cells. AMP-activated protein kinase (AMPK) has previously
been demonstrated to phosphorylate and activate eNOS at Ser-1177 in vitro, yet the ... Cited by 123 - Related articles - BL Direct - All 4 versions
SA Summers - Progress in Lipid Research, 2006 - Elsevier Obesity predisposes individuals to the development of insulin resistance in skeletal muscle and
the liver, and researchers have recently proposed two mechanisms by which excess adiposity
antagonizes insulin action in peripheral tissues. First, when adipocytes exceed their ... Cited by 114 - Related articles - All 3 versions
