BN Finck, X Han, M Courtois, F Aimond, … - Proceedings of the …, 2003 - National Acad Sciences To explore the role of peroxisome proliferator-activated receptor α (PPARα)-mediated derangements
in myocardial metabolism in the pathogenesis of diabetic cardiomyopathy, insulinopenic mice
with PPARα deficiency (PPARα −/− ) or cardiac-restricted overexpression [myosin heavy ... Cited by 210 - Related articles - BL Direct - All 12 versions
- ►nih.gov JM Huss, DP Kelly - Journal of Clinical Investigation, 2005 - Am Soc Clin Investig All cellular processes are driven by ATP-dependent pathways. The heart has perpetually high
energy demands related to the maintenance of specialized cellular processes, including ion
transport, sarcomeric function, and intracellular Ca 2+ homeostasis. Myocardial workload ( ... Cited by 138 - Related articles - All 9 versions
S Boudina, ED Abel - Circulation, 2007 - Am Heart Assoc The prevalence of diabetes mellitus is growing rapidly. It is estimated that globally the number
of adults affected with diabetes will increase from 135 million in 1995 to 300 million by 2025.
1 Patients with diabetes mellitus are at increased risk for cardiovascular diseases. Thus, ... Cited by 140 - Related articles - All 5 versions
- ►fasebj.org RT Jagoe, SH Lecker, M Gomes, AL Goldberg - The FASEB Journal, 2002 - FASEB During fasting and many systemic diseases, muscle undergoes rapid loss of protein and functional
capacity. To define the transcriptional changes triggering muscle atrophy and energy conservation
in fasting, we used cDNA microarrays to compare mRNAs from muscles of control and ... Cited by 125 - Related articles - BL Direct - All 6 versions
G Ye, NS Metreveli, J Ren, PN Epstein - Diabetes, 2003 - Am Diabetes Assoc Many individuals with diabetes experience impaired cardiac contractility that cannot be explained
by hypertension and atherosclerosis. This cardiomyopathy may be due to either organ-based
damage, such as fibrosis, or to direct damage to cardiomyocytes. Reactive oxygen ... Cited by 105 - Related articles - BL Direct - All 5 versions
- ►nih.gov [PDF] M Yamamoto, G Yang, C Hong, J Liu, E … - Journal of Clinical …, 2003 - Am Soc Clin Investig Thioredoxin 1 (Trx1) has redox-sensitive cysteine residues and acts as an antioxidant in
cells. However, the extent of Trx1 contribution to overall antioxidant mechanisms is unknown
in any organs. We generated transgenic mice with cardiac-specific overexpression of a ... Cited by 111 - Related articles - BL Direct - All 7 versions
- ►physiology.org X Shen, S Zheng, V Thongboonkerd, M Xu … - American Journal of …, 2004 - Am Physiological Soc Diabetic cardiomyopathy is a common complication leading to heightened risk of heart failure
and death. In the present report, we performed proteomic analysis on total cardiac proteins from
the OVE26 mouse model of type 1 diabetes to identify protein changes that may ... Cited by 71 - Related articles - BL Direct - All 4 versions
- ►physiology.org [PDF] YJ Chen, S Park, Y Li, E Missov, M Hou, X … - Physiological …, 2003 - Am Physiological Soc Page 1. 1 Alterations of Gene Expression in Failing Myocardium Following Left Ventricular
Assist Device Support YingJie Chen, Soon Park, Yunfang Li, Emil Missov, Mingxiao Hou,
Xinqiang Han, Jennifer L. Hall, Leslie W. Miller, Robert J. Bache ... Cited by 65 - Related articles - BL Direct - All 3 versions
F Fiordaliso, R Bianchi, L Staszewsky, I Cuccovillo, … - Journal of molecular and …, 2004 - Elsevier Diabetes and oxidative stress concur to cardiac myocyte death in various experimental
settings. We assessed whether N-acetyl-l-cysteine (NAC), an antioxidant and glutathione
precursor, has a protective role in a rat model of streptozotocin (STZ)-induced diabetes ... Cited by 62 - Related articles - All 7 versions
