- ►nih.gov MH Zou, C Shi, RA Cohen - Journal of Clinical Investigation, 2002 - Am Soc Clin Investig Nitric oxide (NO) is produced by NO synthase (NOS) in many cells and plays important roles
in the neuronal, muscular, cardiovascular, and immune systems. In various disease
conditions, all three types of NOS (neuronal, inducible, and endothelial) are reported to ... Cited by 325 - Related articles - BL Direct - All 9 versions
JM Forbes, ME Cooper, V Thallas, WC Burns, MC … - Diabetes, 2002 - Am Diabetes Assoc Diabetes is characterized by chronic hyperglycemia, which facilitates nonenzymatic browning
in the Maillard reaction between reducing sugars and free reactive amino groups of proteins
(1). Subsequent biochemical modifications result in the irreversible formation of a ... Cited by 194 - Related articles - BL Direct - All 5 versions
- ►aspetjournals.org IV Turko, F Murad - Pharmacological reviews, 2002 - ASPET There is growing evidence that cardiovascular disease is associated with progressive changes
in the production of free radicals and radical-derived reactive species. These intermediates react
with all major cellular constituents and may serve several physiological and ... Cited by 186 - Related articles - BL Direct - All 4 versions
MH Zou, SS Kirkpatrick, BJ Davis, JS Nelson, WG … - Journal of Biological …, 2004 - ASBMB Metformin, one of the most commonly used drugs for the treatment of type II diabetes, was recently
found to exert its therapeutic effects, at least in part, by activating the AMP-activated protein kinase
(AMPK). However, the site of its action, as well as the mechanism to activate AMPK, ... Cited by 127 - Related articles - BL Direct - All 7 versions
MH Zou, XY Hou, CM Shi, D Nagata, K Walsh, RA … - Journal of Biological …, 2002 - ASBMB Peroxynitrite (ONOO ), a nitric oxide-derived oxidant, uncouples endothelial nitric oxide synthase
(eNOS) and increases enzymatic production of superoxide anions (O ) (Zou, MH, Shi, C., and
Cohen, RA (2002) J. Clin. Invest. 109, 817-826). Here we studied how ONOO influences ... Cited by 116 - Related articles - BL Direct - All 6 versions
MH Zou, RA Cohen, V Ullrich - Endothelium, 2004 - informahealthcare.com Macro and microvascular diseases are the principal causes of morbidity and mortality in patients
with type I and II diabetes mellitus. Growing evidence implicates reactive nitrogen species
(RNS), such as peroxynitrite (ONOO − ), derived from nitric oxide (NO) and superoxide ... Cited by 101 - Related articles - BL Direct - All 5 versions
- ►jbc.org MH Zou, XY Hou, CM Shi, S Kirkpatick, F Liu, MH … - Journal of Biological …, 2003 - ASBMB AMP-activated kinase (AMPK) is a fuel-sensing enzyme present in most mammalian tissue. In
response to a decrease in the energy state of a cell AMPK is phosphorylated and activated by
still poorly characterized upstream events. Exposure of bovine aortic endothelial cells ( ... Cited by 95 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org BJ Davis, Z Xie, B Viollet, MH Zou - Diabetes, 2006 - Am Diabetes Assoc Metformin, one of most commonly used drugs for the treatment of type 2 diabetes, improves vascular
endothelial functions and reduces cardiovascular events in patients with type 2 diabetes, although
its mechanisms remain unknown. The current study aimed to elucidate how metformin ... Cited by 92 - Related articles - BL Direct - All 6 versions
RB Caldwell, M Bartoli, MA Behzadian, AEB … - Diabetes/Metabolism … - interscience.wiley.com Retinal neovascularization and macular edema are central features of diabetic retinopathy, the
major cause of blindness in the developed world. Current treatments are limited in their efficacy
and are associated with significant adverse effects. Characterization of the molecular and ... Cited by 90 - Related articles - BL Direct - All 3 versions
