- ►jimmunol.org N Giarratana, G Penna, S Amuchastegui, R … - The Journal of Immunology, 2004 - Am Assoc Immnol Type 1 diabetes (T1D) is an autoimmune disease characterized by leukocyte
infiltration into the pancreatic islets, and we have previously shown that
treatment of adult NOD mice with a vitamin D analog arrests the progression ... Cited by 67 - Related articles - BL Direct - All 4 versions
- ►harvard.edu [PDF] LS Wicker, J Clark, HI Fraser, VES Garner, A … - Journal of Autoimmunity, 2005 - Elsevier The identification of causative genes for the autoimmune disease type 1 diabetes
(T1D) in humans and candidate genes in the NOD mouse has made significant
progress in recent years. In addition to sharing structural aspects of the ... Cited by 42 - Related articles - All 6 versions
- ►jimmunol.org LM Esteban, T Tsoutsman, MA Jordan, D Roach … - The Journal of Immunology, 2003 - Am Assoc Immnol Natural killer T cells are an immunoregulatory population of lymphocytes that
plays a critical role in controlling the adaptive immune system and contributes
to the regulation of autoimmune responses. We have previously reported ... Cited by 35 - Related articles - BL Direct - All 4 versions
- ►jimmunol.org M Jagodic, K Becanovic, JR Sheng, X Wu, L … - The Journal of Immunology, 2004 - Am Assoc Immnol Identification of polymorphic genes regulating inflammatory diseases may unravel
crucial pathogenic mechanisms. Initial steps to map such genes using linkage
analysis in F 2 intercross or backcross populations, however, result in ... Cited by 31 - Related articles - BL Direct - All 5 versions
K Raman, C Mohan - Current opinion in immunology, 2003 - Elsevier Autoimmunity has been studied for more than four decades, but its genetic
origins have remained a mystery. The recent past has witnessed an exponential
growth in our understanding of autoimmunity resulting from both forward and ... Cited by 24 - Related articles - All 4 versions
Z Yang, M Chen, JD Ellett, LB Fialkow, JD … - Journal of Autoimmunity, 2004 - Elsevier Signal transducers and activators of transcription (STAT) proteins are activated
in response to many cytokines, growth factors and hormones. STAT4 mediates IL-12
signaling and regulates T helper 1 (Th1) cell differentiation. Both IL-12 ... Cited by 24 - Related articles - All 4 versions
Y Yang, P Santamaria - Diabetologia, 2003 - Springer Type 1 diabetes results from a genetically and immu- nologically complex
autoimmune process that is spe- cifically directed against the pancreatic beta
cells. Non-obese diabetic mice spontaneously develop a form of autoimmune ... Cited by 21 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org TC Brodnicki, F Quirk, G Morahan - Diabetes, 2003 - Am Diabetes Assoc The nonobese diabetic (NOD) mouse is genetically predisposed for the spontaneous
development of type 1 diabetes. Linkage analyses have identified at least 19
susceptibility loci (Idd1–Idd19) that contribute to disease pathogenesis ... Cited by 18 - Related articles - BL Direct - All 5 versions
ML Bergman, N Duarte, S Campino, M … - Diabetes, 2003 - Am Diabetes Assoc Type 1 diabetes in the nonobese diabetic (NOD) mouse is a multifactorial and
polygenic disease. The NOD-derived genetic factors that contribute to type 1
diabetes are named Idd (insulin-dependent diabetes) loci. To date, the ... Cited by 17 - Related articles - BL Direct - All 4 versions
- ►nih.gov MA Atkinson, SB Wilson - Journal of Clinical Investigation, 2002 - Am Soc Clin Investig Research discoveries within the past few years have dramatically reshaped our
collective thought on the pathogenesis and natural history of type 1 diabetes
(1). Many concepts once held as dogmas (eg, B lymphocytes play no ... Cited by 17 - Related articles - BL Direct - All 7 versions
