- ►bloodjournal.org V Sordi, ML Malosio, F Marchesi, A Mercalli, R Melzi, T … - Blood, 2005 - Am Soc Hematology Bone marrow–derived mesenchymal stem cells (BM-MSCs) are stromal cells with the ability
to proliferate and differentiate into many tissues. Although they represent powerful tools for several
therapeutic settings, mechanisms regulating their migration to peripheral tissues are still ... Cited by 142 - Related articles - BL Direct - All 4 versions
B Kutlu, AK Cardozo, MI Darville, M Kruhoffer … - DIABETES-NEW …, 2003 - Am Diabetes Assoc Locally released cytokines contribute to -cell dysfunc- tion and apoptosis in type 1 diabetes. In
vitro exposure of insulin-producing INS-1E cells to the cytokines inter- leukin (IL)-1 interferon
(IFN)- leads to a signifi- cant increase in apoptosis. To characterize the genetic networks ... Cited by 91 - Related articles - BL Direct - All 7 versions
AK Cardozo, P Proost, C Gysemans, MC Chen, C … - Diabetologia, 2003 - Springer Aims/hypothesis. Cytokines and chemokines are im- portant mediators of immune responses
due to their ability to recruit and activate leukocytes. Using micro- array analysis we observed
that rat beta cells exposed to IL-1β and IFN-γ have increased mRNA levels of chemokines ... Cited by 86 - Related articles - BL Direct - All 5 versions
- ►alphamedpress.org TD Zorina, VM Subbotin, S Bertera, AM Alexander, C … - Stem Cells, 2003 - AlphaMed Press In light of accumulating evidence that the endocrine pancreas has regenerative properties and
that hematopoietic chimerism can abrogate destruction of ß cells in autoimmune diabetes, we
addressed the question of whether recovery of physiologically adequate endogenous ... Cited by 80 - Related articles - BL Direct - All 5 versions
H Johansson, A Lukinius, L Moberg, T Lundgren, C … - Diabetes, 2005 - Am Diabetes Assoc There are strong indications that only a small fraction of grafts successfully engraft in clinical
islet transplantation. One explanation may be the instant blood-mediated inflammatory reaction
(IBMIR) elicited by tissue factor, which is produced by the endocrine cells. In the present ... Cited by 80 - Related articles - All 6 versions
T El-Sawy, NM Fahmy, RL Fairchild - Current opinion in immunology, 2002 - Elsevier Rejection of transplanted organs remains a significant obstacle to the long-term treatment of
end-stage organ disease. Acute rejection of allografts is initiated by alloantigen-specific T cells
that respond to inflammatory stimuli and infiltrate the graft, where they are activated to ... Cited by 75 - Related articles - All 4 versions
- ►diabetesjournals.org R Bottino, AN Balamurugan, H Tse, C … - Diabetes, 2004 - Am Diabetes Assoc The process of human islet isolation triggers a cascade of stressful events in the islets of Langerhans
involving activation of apoptosis and necrosis and the production of proinflammatory molecules
that negatively influence islet yield and function and may produce detrimental effects after ... Cited by 72 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org L Piemonti, G Calori, A Mercalli, G Lattuada, P … - Diabetes Care, 2003 - Am Diabetes Assoc CONCLUSIONS—In middle-aged women, MCP-1/CCL2, leptin, and TNF-α-R2 were all related
to biochemical risk markers of atherosclerosis. MCP-1/CCL2 concentration was the only one
to be increased in type 2 diabetes with respect to nondiabetic women and the only one to ... Cited by 70 - Related articles - BL Direct - All 7 versions
- ►jimmunol.org N Giarratana, G Penna, S Amuchastegui, R … - The Journal of …, 2004 - Am Assoc Immnol Type 1 diabetes (T1D) is an autoimmune disease characterized by leukocyte infiltration into the
pancreatic islets, and we have previously shown that treatment of adult NOD mice with a vitamin
D analog arrests the progression of insulitis, blocks Th1 cell infiltration into the pancreas, ... Cited by 68 - Related articles - BL Direct - All 4 versions
U Johansson, A Olsson, S Gabrielsson, B Nilsson, … - … and Biophysical Research …, 2003 - Elsevier Expression of immune modulating mediators in human Islets of Langerhans could have important
implications for development of autoimmunity in type 1 diabetes and influence the outcome of
clinical islet transplantation. Islets obtained from five donors were analyzed at various ... Cited by 67 - Related articles - All 5 versions
