AE Butler, J Janson, S Bonner-Weir, R Ritzel, RA Rizza … - Diabetes, 2003 - Am Diabetes Assoc Type 2 diabetes is characterized by impaired insulin secretion. Some but not all studies suggest
that a decrease in β-cell mass contributes to this. We examined pancreatic tissue from 124
autopsies: 91 obese cases (BMI >27 ... Cited by 958 - Related articles - BL Direct - All 4 versions
S Oyadomari, E Araki, M Mori - Apoptosis, 2002 - Springer Apoptotic cell death in pancreatic β -cells is involved in the pathogenesis of diabetes. Signals
from death recep- tors and DNA damage have been widely accepted as be- ing triggers of apoptosis in
β -cells. Recent studies indi- ... Cited by 217 - Related articles - BL Direct - All 4 versions
AE Butler, J Janson, WC Soeller, PC Butler - Diabetes, 2003 - Am Diabetes Assoc Nondiabetic obese humans adapt to insulin resistance by increasing β-cell mass. In contrast, obese
humans with type 2 diabetes have an ∼60% deficit in β-cell mass. Recent studies in rodents reveal
that β-cell mass is regulated, ... Cited by 146 - Related articles - BL Direct - All 6 versions
N Zhang, A Richter, J Suriawinata, S Harbaran, J … - Diabetes, 2004 - Am Diabetes Assoc Successful islet transplantation depends on the infusion of sufficiently large quantities of islets,
of which only ∼30% become stably engrafted. Rapid and adequate revascularization of transplanted
islets is important for islet ... Cited by 80 - Related articles - BL Direct - All 6 versions
X Li, H Chen, PN Epstein - Journal of Biological Chemistry, 2004 - ASBMB Islet transplantation is a promising therapy for Type 1 diabetes, but many attempts have failed due
to early graft hypoxia or immune rejection, which generate reactive oxygen species (ROS). In the
current study, we determined that ... Cited by 66 - Related articles - BL Direct - All 5 versions
- ►jleukbio.org NR Barshes, S Wyllie, JA Goss - Journal of leukocyte biology, 2005 - Soc Leukocyte Biology Recent advances in clinical protocols have improved the outcomes of pancreatic islet transplantation
(PIT), yet PIT recipients typically require pancreatic islet grafts derived from multiple donors to
achieve insulin independence. This ... Cited by 56 - Related articles - All 8 versions
- ►jbc.org A Garcia-Ocana, KK Takane, VT Reddy, JC Lopez- … - Journal of Biological …, 2003 - ASBMB Hepatocyte growth factor (HGF) increases beta cell proliferation and function in rat insulin
promoter (RIP)-targeted transgenic mice. RIP-HGF mouse islets also function superiorly to normal
islets in a transplant setting. ... Cited by 56 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org NV Evgenov, Z Medarova, J Pratt, P Pantazopoulos, S … - Diabetes, 2006 - Am Diabetes Assoc As islet transplantation becomes an acceptable clinical modality for restoring normoglycemia in type
1 diabetic patients, there is a crucial need for noninvasive assessment of the fate of the grafts.
In spite of the success of the ... Cited by 48 - Related articles - BL Direct - All 5 versions
- ►jimmunol.org ST Grey, C Longo, T Shukri, VI Patel, E … - The Journal of …, 2003 - Am Assoc Immnol Transplantation of an excessive number of islets of Langerhans (two to four pancreata per recipient)
into patients with type I diabetes is required to restore euglycemia. Hypoxia, nutrient deprivation,
local inflammation, and the cell ... Cited by 44 - Related articles - BL Direct - All 4 versions
- ►endojournals.org W Liu, C Chin-Chance, EJ Lee, WL Lowe Jr - Endocrinology, 2002 - Endocrine Soc To begin to determine whether IGF-I treatment represents a potential means of enhancing the survival
of islet cell grafts after transplantation, the present studies established a model of ß-cell death
secondary to loss of trophic ... Cited by 43 - Related articles - BL Direct - All 5 versions
