- ►sb-roscoff.fr [PDF] L Meijer, M Flajolet, P Greengard - Trends in pharmacological sciences, 2004 - Elsevier Three closely related forms of glycogen synthase kinase 3 (GSK-3α, GSK-3β and
GSK-3β2) have a major role in Wnt and Hedgehog signaling pathways and regulate
the cell-division cycle, stem-cell renewal and differentiation, apoptosis, ... Cited by 186 - Related articles - All 12 versions
EJ McManus, K Sakamoto, LJ Armit, L … - The EMBO Journal, 2005 - pubmedcentral.nih.gov The inactivation of glycogen synthase kinase (GSK)3 has been proposed to play
important roles in insulin and Wnt signalling. To define the role that
inactivation of GSK3 plays, we generated homozygous knockin mice in which ... Cited by 141 - Related articles - All 6 versions
- ►physiology.org A Barthel, D Schmoll - American Journal of Physiology- Endocrinology And …, 2003 - Am Physiological Soc The regulation of hepatic gluconeogenesis is an important process in the
adjustment of the blood glucose level, and pathological changes in the glucose
production of the liver are a central characteristic in type 2 diabetes. ... Cited by 123 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org K Morino, KF Petersen, GI Shulman - Diabetes, 2006 - Am Diabetes Assoc Recent studies using magnetic resonance spectroscopy have shown that decreased
insulin-stimulated muscle glycogen synthesis due to a defect in
insulin-stimulated glucose transport activity is a major factor in the ... Cited by 123 - Related articles - BL Direct - All 5 versions
DB Ring, KW Johnson, EJ Henriksen, JM Nuss … - Diabetes, 2003 - Am Diabetes Assoc Insulin resistance plays a central role in the development of type 2 diabetes,
but the precise defects in insulin action remain to be elucidated. Glycogen
synthase kinase 3 (GSK-3) can negatively regulate several aspects of ... Cited by 104 - Related articles - BL Direct - All 4 versions
JJ Trowbridge, A Xenocostas, RT Moon, M … - Nature medicine, 2006 - fhs.mcmaster.ca The in vivo regulation of hematopoietic stem cell (HSC) function is poorly
understood. Here, we show that hematopoietic repopulation can be augmented by
administration of a glycogen synthase kinase-3 (GSK-3) inhibitor to ... Cited by 91 - Related articles - BL Direct - All 7 versions
PM Fischer - Current medicinal chemistry, 2004 - ingentaconnect.com Abstract: The human genome encompasses some 2,000 proteins that utilize
adenosine 5'-triphosphate (ATP) in one way or another and some 500 of these are
protein-tyrosine and protein-serine/threonine kinases (PTKs & PSTKs). ... Cited by 72 - Related articles - BL Direct - All 5 versions
- ►nih.gov RS Jope, CJ Yuskaitis, E Beurel - Neurochemical research, 2007 - Springer Abstract Deciphering what governs inflammation and its effects on tissues is
vital for understanding many pathologies. The recent discovery that glycogen
synthase kinase-3 (GSK3) promotes inflammation reveals a new component of ... Cited by 72 - Related articles - BL Direct - All 5 versions
- ►aspetjournals.org B Plotkin, O Kaidanovich, I Talior, H Eldar- … - Journal of Pharmacology and Experimental …, 2003 - ASPET Glycogen synthase kinase-3 (GSK-3) was shown to be a key factor in attenuation
of the cellular action of insulin. We speculated that inhibition of GSK-3 might
have a potential therapeutic value in treatment of insulin resistance and ... Cited by 63 - Related articles - BL Direct - All 4 versions
Z Liberman, H Eldar-Finkelman - Journal of Biological Chemistry, 2005 - ASBMB The ability of glycogen synthase kinase-3 (GSK-3) to phosphorylate insulin
receptor substrate-1 (IRS-1) is a potential inhibitory mechanism for insulin
resistance in type 2 diabetes. However, the serine site(s) phosphorylated ... Cited by 59 - Related articles - All 5 versions
