- ►sallyosborne.com [PDF] JE Schaffer - Current opinion in lipidology, 2003 - journals.lww.com Recent findings: Excess lipid accumulation in non-adipose tissues may arise in
the setting of high plasma free fatty acids or triglycerides. Alternatively,
lipid overload results from mismatch between free fatty acid import and ... Cited by 196 - Related articles - BL Direct - All 8 versions
YB Kim, K Kotani, TP Ciaraldi, RR Henry, BB … - Diabetes, 2003 - Am Diabetes Assoc In humans with obesity or type 2 diabetes, insulin target tissues are resistant
to many actions of insulin. The atypical protein kinase C (PKC) isoforms λ and
ζ are downstream of phosphatidylinositol-3 kinase (PI3K) and are required ... Cited by 79 - Related articles - BL Direct - All 5 versions
- ►leptipro.org [PDF] JM Zabolotny, FG Haj, YB Kim, HJ Kim, GI … - Journal of Biological Chemistry, 2004 - ASBMB Previous studies implicate protein-tyrosine phosphatase 1B (PTP1B) and leukocyte
antigen-related phosphatase (LAR) as negative regulators of insulin signaling.
The expression and/or activity of PTP1B and LAR are increased in muscle of ... Cited by 55 - Related articles - BL Direct - All 8 versions
- ►ajcn.org MP Corcoran, S Lamon-Fava, RA Fielding - American Journal of Clinical Nutrition, 2007 - Am Soc Nutrition Mounting evidence indicates that elevated intramyocellular triacylglycerol
concentrations are associated with diminished insulin sensitivity in skeletal
muscle. This lipid accumulation is most likely due to enhanced fatty acid ... Cited by 36 - Related articles - BL Direct - All 12 versions
- ►cell.com N Furukawa, P Ongusaha, WJ Jahng, K Araki, … - Cell Metabolism, 2005 - Elsevier Accumulating evidence indicates an important role for serine phosphorylation of
IRS-1 in the regulation of insulin action. Recent studies suggest that
Rho-kinase (ROK) is a mediator of insulin signaling, via interaction with ... Cited by 34 - Related articles - All 11 versions
R Farese, M Sajan, M Standaert - Biochemical Society Transactions, 2005 - bst.portlandpress.com It now seems clear that aPKC (atypical protein kinase C) isoforms are required
for insulin-stimulated glucose transport in muscle and adipocytes. Moreover,
there are marked defects in the activation of aPKCs under a variety of ... Cited by 34 - Related articles - Cached - All 9 versions
ML Standaert, MP Sajan, A Miura, Y Kanoh, … - Journal of Biological Chemistry, 2004 - ASBMB Insulin resistance in type 2 diabetes is characterized by defects in muscle
glucose uptake and hepatic overproduction of both glucose and lipids. These
hepatic defects are perplexing because insulin normally suppresses glucose ... Cited by 31 - Related articles - BL Direct - All 4 versions
JN Nielsen, C Frøsig, MP Sajan, A Miura, ML … - Biochemical and Biophysical Research …, 2003 - Elsevier Exercise training may modulate protein content and enzyme activities in skeletal
muscle. However, it is not known whether atypical protein kinase C (aPKC) is
affected by training. Thus, we investigated aPKC, extracellular-regulated ... Cited by 30 - Related articles - All 5 versions
AP Russell - International Journal of Obesity, 2004 - nature.com The potential lipotoxic effect of intramyocellular triglyceride (IMTG)
accumulation has been suggested to be a major component in the development of
insulin resistance. Increased levels of IMTGs correlate with insulin ... Cited by 26 - Related articles - All 5 versions
- ►molbiolcell.org LZ Liu, HL Zhao, J Zuo, SKS Ho, JCN Chan, … - Molecular biology of the cell, 2006 - Am Soc Cell Biol Protein kinase C (PKC) has been implicated in insulin-induced glucose uptake in
skeletal muscle cell, although the underlying mechanism remains unknown. In this
study, we investigated the effect of PKC on actin remodeling and glucose ... Cited by 23 - Related articles - BL Direct - All 6 versions
