- ►drclaudiaanrig.com [PDF] RH Eckel, SM Grundy, PZ Zimmet - The Lancet, 2005 - Elsevier The metabolic syndrome is a common metabolic disorder that results from the
increasing prevalence of obesity. The disorder is defined in various ways, but
in the near future a new definition(s) will be applicable worldwide. The ... Cited by 1560 - Related articles - All 41 versions
VK Mootha, CM Lindgren, KF Eriksson, A … - Nature genetics, 2003 - ws1.izbi.uni-leipzig.de Type 2 diabetes mellitus (DM2) affects over 110 million people world- wide and
is a principal contributor to atherosclerotic vascular disease, blindness,
amputation and kidney failure 1 . Defects in insulin secretion are observed ... Cited by 1289 - Related articles - BL Direct - All 24 versions
- ►upmc.fr [PDF] KF Petersen, D Befroy, S Dufour, J Dziura, C … - Science, 2003 - sciencemag.org 420 article(s) on the ISI Web of Science. cited by This article has been ... :
subject collections This article appears in the following ... 2003 by the
American Association for the Advancement of Science; all rights reserved. ... Cited by 695 - Related articles - All 14 versions
- ►pnas.org ME Patti, AJ Butte, S Crunkhorn, K Cusi, R … - Proceedings of the National Academy of Sciences, 2003 - National Acad Sciences Type 2 diabetes mellitus (DM) is characterized by insulin resistance and
pancreatic β cell dysfunction. In high-risk subjects, the earliest detectable
abnormality is insulin resistance in skeletal muscle. Impaired ... Cited by 663 - Related articles - BL Direct - All 15 versions
BB Lowell, GI Shulman - Science, 2005 - sciencemag.org Type 2 diabetes is the most common metabolic disease in the world. In the United
States, it is the leading cause of blindness, end-stage renal disease, and
nontraumatic loss of limb, with associated health care costs estimated to ... Cited by 506 - Related articles - All 6 versions
- ►harvard.edu [PDF] M Stumvoll, BJ Goldstein, TW van Haeften - The Lancet, 2005 - Elsevier Type 2 diabetes mellitus has become an epidemic, and virtually no physician is
without patients who have the disease. Whereas insulin insensitivity is an early
phenomenon partly related to obesity, pancreas β-cell function declines ... Cited by 433 - Related articles - All 17 versions
J Lin, C Handschin, BM Spiegelman - Cell metabolism, 2005 - Elsevier Many complex biological programs are controlled at the level of gene
transcription by DNA binding transcription factors. Recent studies have revealed
a novel mode of regulation by coactivator proteins, best illustrated by the ... Cited by 366 - Related articles - All 13 versions
- ►endojournals.org H Bays, L Mandarino, RA DeFronzo - Journal of Clinical Endocrinology & Metabolism, 2004 - Endocrine Soc Type 2 diabetes mellitus (T2DM) is characterized by insulin resistance in liver
and muscle and impaired insulin secretion. Considerable evidence also implicates
deranged adipocyte metabolism and altered fat topography in the ... Cited by 245 - Related articles - All 4 versions
- ►nih.gov VK Mootha, C Handschin, D Arlow, X Xie, J St … - Proceedings of the National Academy of Sciences, 2004 - National Acad Sciences Recent studies have shown that genes involved in oxidative phosphorylation
(OXPHOS) exhibit reduced expression in skeletal muscle of diabetic and
prediabetic humans. Moreover, these changes may be mediated by the ... Cited by 242 - Related articles - BL Direct - All 14 versions
- ►shouxi.net VB Ritov, EV Menshikova, J He, RE Ferrell, … - Diabetes, 2005 - Am Diabetes Assoc The current study addresses a novel hypothesis of subcellular distribution of
mitochondrial dysfunction in skeletal muscle in type 2 diabetes. Vastus
lateralis muscle was obtained by percutaneous biopsy from 11 volunteers ... Cited by 194 - Related articles - All 6 versions
