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Scholar Results 1 - 10 of about 74 citing Houmard: Effect of weight loss on insulin sensitivity and intramuscular long-chain fatty.... (0.16 sec) 

Lipotoxicity: when tissues overeat

- sallyosborne.com [PDF] 
JE Schaffer - Current opinion in lipidology, 2003 - journals.lww.com
Recent findings: Excess lipid accumulation in non-adipose tissues may arise in
the setting of high plasma free fatty acids or triglycerides. Alternatively,
lipid overload results from mismatch between free fatty acid import and ...
Cited by 197 - Related articles - BL Direct - All 8 versions

Calorie restriction and aging: review of the literature and implications for studies in humans


LK Heilbronn, E Ravussin - American Journal of Clinical Nutrition, 2003 - Am Soc Nutrition
Calorie restriction (CR) extends life span and retards age-related chronic
diseases in a variety of species, including rats, mice, fish, flies, worms, and
yeast. The mechanism or mechanisms through which this occurs are unclear. ...
Cited by 189 - Related articles - BL Direct - All 9 versions

Gastric bypass for obesity: mechanisms of weight loss and diabetes resolution

- endojournals.org
DE Cummings, J Overduin, KE Foster- … - Journal of Clinical Endocrinology & Metabolism, 2004 - Endocrine Soc
Obesity is now a global pandemic that continues to accelerate despite the often
Herculean efforts by afflicted individuals to lose weight. These efforts are
thwarted by a physiological system that regulates body weight in a manner ...
Cited by 157 - Related articles - BL Direct - All 6 versions

Insulin and its evolving partnership with leptin in the hypothalamic control of energy …


KD Niswender, DG Baskin, MW Schwartz - Trends in Endocrinology & Metabolism, 2004 - Elsevier
Despite an alarming increase in the burden of obesity worldwide, body adiposity
seems to be a regulated physiological variable. Regulation of adiposity occurs
through a classical endocrine feedback loop, in which the pancreatic ...
Cited by 104 - Related articles - All 8 versions

Adiponectin levels in women with polycystic ovary syndrome

- endojournals.org
F Orio Jr, S Palomba, T Cascella, G Milan, R … - Journal of Clinical Endocrinology & Metabolism, 2003 - Endocrine Soc
The adipose tissue not only stores a large quantity of fat as an energy source
(4) but also expresses a variety of genes of secretory proteins (5, 6, 7, 8, 9).
The human apM1 gene has been recently discovered, and it is exclusively ...
Cited by 98 - Related articles - BL Direct - All 5 versions

Muscle oxidative capacity is a better predictor of insulin sensitivity than lipid status

- endojournals.org
CR Bruce, MJ Anderson, AL Carey, DG … - Journal of Clinical Endocrinology & Metabolism, 2003 - Endocrine Soc
We determined whole-body insulin sensitivity, long-chain fatty acyl coenzyme A
(LCACoA) content, skeletal muscle triglyceride (TG m ) concentration, fatty acid
transporter protein content, and oxidative enzyme activity in eight ...
Cited by 80 - Related articles - BL Direct - All 6 versions

Long-Term Improvement in Insulin Sensitivity by Changing Lifestyles of People with …


M Uusitupa, V Lindi, A Louheranta, T Salopuro … - Diabetes, 2003 - Am Diabetes Assoc
Lifestyle interventions reduce the incidence of type 2 diabetes among
individuals with impaired glucose tolerance (IGT). However, it is unknown
whether this is due to improved insulin sensitivity or insulin secretion. ...
Cited by 80 - Related articles - BL Direct - All 8 versions

Diabetes: insulin resistance and derangements in lipid metabolism. Cure through intervention …


I Raz, R Eldor, S Cernea, E Shafrir - Diabetes/Metabolism Reviews - interscience.wiley.com
We present multiple findings on derangements in lipid metabolism in type 2
diabetes. The increase in the intracellular deposition of triglycerides (TG) in
muscles, liver and pancreas in subjects prone to diabetes is well ...
Cited by 71 - Related articles - All 3 versions

Endurance training in obese humans improves glucose tolerance and mitochondrial fatty acid …

- physiology.org
CR Bruce, A Thrush, VA Mertz, V Bezaire, A … - American Journal of Physiology- Endocrinology And …, 2006 - Am Physiological Soc
Muscle fatty acid (FA) metabolism is impaired in obesity and insulin resistance,
reflected by reduced rates of FA oxidation and accumulation of lipids. It has
been suggested that interventions that increase FA oxidation may enhance ...
Cited by 69 - Related articles - BL Direct - All 5 versions

Differential effects of rosiglitazone on skeletal muscle and liver insulin resistance in A-ZIP/F- …


JK Kim, JJ Fillmore, O Gavrilova, L Chao, T … - Diabetes, 2003 - Am Diabetes Assoc
To determine the role of adipocytes and the tissue-specific nature in the
insulin sensitizing action of rosiglitazone, we examined the effects of 3 weeks
of rosiglitazone treatment on insulin signaling and action during ...
Cited by 60 - Related articles - BL Direct - All 5 versions


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