D Jay, H Hitomi, KK Griendling - Free Radical Biology and Medicine, 2006 - Elsevier Diabetes diagnoses are increasing at an alarming rate worldwide. The majority of
diabetes-related deaths arise from cardiovascular complications such as
myocardial infarction, stroke, and peripheral vascular disease. Oxidative ... Cited by 109 - Related articles - All 4 versions
JM Zingg, A Azzi - Current medicinal chemistry, 2004 - ingentaconnect.com Abstract: Molecules in biological systems often can perform more than one
function. In particular, many molecules have the ability to chemically scavenge
free radicals and thus act in the test tube as antioxidant, but their main ... Cited by 105 - Related articles - BL Direct - All 4 versions
- ►ahajournals.org C Rask-Madsen, GL King - Arteriosclerosis, thrombosis, and vascular biology, 2005 - Am Heart Assoc In diabetes and insulin resistance, activation of protein kinase C (PKC) in
vascular cells may be a key link between elevated plasma and tissue
concentrations of glucose and nonesterified fatty acids and abnormal ... Cited by 84 - Related articles - All 9 versions
- ►diabetesjournals.org S Devaraj, SK Venugopal, U Singh, I Jialal - Diabetes, 2005 - Am Diabetes Assoc Diabetes confers an increased propensity to atherosclerosis. Inflammation is
pivotal in atherogenesis, and diabetes is a proinflammatory state. Interleukin
(IL)-6, in addition to inducing the acute-phase response, contributes to ... Cited by 67 - Related articles - All 5 versions
SW Ballinger - Free Radical Biology and Medicine, 2005 - Elsevier Whereas the pathogenesis of atherosclerosis has been intensively studied and
described, the underlying events that initiate cardiovascular disease are not
yet fully understood. A substantial number of studies suggest that altered ... Cited by 63 - Related articles - All 6 versions
JA Scott, GL King - Ann NY Acad Sci, 2004 - interscience.wiley.com Abstract: The many studies on oxidative stress, antioxidant treatment, and
diabetic complications have shown that oxidative stress is increased and may
accelerate the development of complications through the metabolism of ... Cited by 53 - Related articles - All 6 versions
S Shaw, X Wang, H Redd, GD Alexander, CM … - Journal of Biological Chemistry, 2003 - ASBMB Angiotensin II (Ang II), protein kinase C (PKC), reactive oxygen species (ROS)
generated by NADPH oxidase, the activation of Janus kinase 2 (JAK2), and the
polyol pathway play important parts in the hyperproliferation of vascular ... Cited by 55 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org S Devaraj, N Glaser, S Griffen, J Wang- … - Diabetes, 2006 - Am Diabetes Assoc Type 1 diabetes is associated with increased vascular complications, and
monocytes are pivotal cells in atherogenesis. However, there are few data on
monocyte function and inflammation in type 1 diabetes. The aim of this ... Cited by 54 - Related articles - BL Direct - All 6 versions
DM Niedowicz, DL Daleke - Cell biochemistry and biophysics, 2005 - Springer The morbidity and mortality associated with diabetes is the result of the myriad
complications related to the disease. One of the most explored hypotheses to
explain the onset of complications is a hyperglycemia-induced increase in ... Cited by 52 - Related articles - BL Direct - All 6 versions
