- ►endojournals.org SK Srivastava, KV Ramana, A Bhatnagar - Endocrine reviews, 2005 - Endocrine Soc Aldose reductase (AR) is widely expressed aldehyde-metabolizing enzyme. The
reduction of glucose by the AR-catalyzed polyol pathway has been linked to the
development of secondary diabetic complications. Although treatment with AR ... Cited by 97 - Related articles - All 6 versions
KV Ramana, B Friedrich, S Srivastava, A … - Diabetes, 2004 - Am Diabetes Assoc Activation of the polyol pathway has been linked to the development of secondary
diabetic complications. However, the underlying molecular mechanisms remain
unclear. To probe the contribution of this pathway, we examined whether ... Cited by 61 - Related articles - BL Direct - All 4 versions
- ►iovs.org AB El-Remessy, G Abou-Mohamed, RW … - Investigative ophthalmology & visual science, 2003 - ARVO PURPOSE. Analyses in diabetic rats have shown that breakdown of the
blood–retina barrier is associated with increased formation of peroxynitrite,
nitric oxide, and lipid peroxidation. The permeability increase is blocked ... Cited by 55 - Related articles - BL Direct - All 4 versions
DM Niedowicz, DL Daleke - Cell biochemistry and biophysics, 2005 - Springer The morbidity and mortality associated with diabetes is the result of the myriad
complications related to the disease. One of the most explored hypotheses to
explain the onset of complications is a hyperglycemia-induced increase in ... Cited by 52 - Related articles - BL Direct - All 6 versions
- ►sav.sk [PDF] Z Kyselova, M Stefek, V Bauer - Journal of diabetes and its complications, 2004 - Elsevier Cataract — opacification of the lens — is closely related to diabetes as one
of its major late complications. This review deals with three molecular
mechanisms that may be involved in the development of diabetic cataract: ... Cited by 31 - Related articles - All 14 versions
J Ren, AF Ceylan-Isik - Endocrine, 2004 - Springer Received August 2, 2004; Revised October 17, 2004; Accepted October 21, 2004.
Author to whom all correspondence and reprint requests should be addressed: Dr.
Jun Ren, Associate Professor, Division of Pharmaceutical Sciences and ... Cited by 31 - Related articles - All 3 versions
- ►chinaphar.com LE Wold, AF Ceylan-Isik, J Ren - Acta Pharmacologica Sinica, 2005 - nature.com Cardiovascular disease is the most common cause of death in the diabetic
population and is currently one of the leading causes of death in the United
States and other industrialized countries. The health care expenses ... Cited by 30 - Related articles - BL Direct - All 8 versions
- ►uwo.ca [PDF] H Farhangkhoee, ZA Khan, H Kaur, X Xin, S … - Pharmacology and Therapeutics, 2006 - Elsevier Cardiovascular complications account for significant morbidity and mortality in
the diabetic population. Diabetic cardiomyopathy, a prominent cardiovascular
complication, has been recognized as a microvascular disease that may lead ... Cited by 31 - Related articles - All 7 versions
MJ Taverna, F Elgrably, H Selmi, JL Selam, G … - Nitric Oxide, 2005 - Elsevier Genetic factors could be implicated in the pathogenesis of severe diabetic
retinopathy (DR). Recently, we reported a strong association between the
eNOS4b/a endothelial nitric oxide synthase (eNOS) polymorphism and severe ... Cited by 19 - Related articles - All 3 versions
- ►amjpathol.org Y Kanetsuna, K Takahashi, M Nagata, MA … - American Journal of Pathology, 2007 - ASIP Recent studies have implicated dysfunctional endothelial nitric-oxide synthase
(eNOS) as a common pathogenic pathway in diabetic vascular complications.
However, functional consequences are still incompletely understood. To ... Cited by 17 - Related articles - BL Direct - All 9 versions
