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Scholar Results 1 - 10 of about 122 citing van Rossum: A polymorphism in the glucocorticoid receptor gene, which decreases sensitivity.... (0.10 sec) 

Common polymorphisms in the glucocorticoid receptor gene are associated with …

- endojournals.org
S Wust, EFC van Rossum, IS Federenko, JW … - Journal of Clinical …, 2004 - Endocrine Soc
Because only four ER22/23EK heterozygotes were identified, these subjects were not statistically
analyzed. Compared with subjects with the wild-type GR genotype (n = 36), 363S allele carriers (n =
10) showed significantly increased ...
Cited by 122 - Related articles - BL Direct - All 6 versions

Polymorphisms in the glucocorticoid receptor gene and their associations with …


EFC van Rossum, SWJ Lamberts - Recent Progress in Hormone …, 2004 - Endocrine Soc
Most actions of glucocorticoids (GCs) are mediated by the glucocorticoid receptor (GR). The
interindividual response to GCs varies considerably, as demonstrated by a variable suppressive
response to 0.25-mg dexamethasone ...
Cited by 113 - Related articles - BL Direct - All 2 versions

[PDF] Hormones and the stressed brain


ER De Kloet - Ann NY Acad Sci, 2004 - people.vcu.edu
ABSTRACT: The stress system orchestrates brain and body responses to the en- vironment. Cortisol (in
humans) or corticosterone (in rodents) are important mediators of the stress system. Their
action—in concert—is crucial ...
Cited by 89 - Related articles - View as HTML - BL Direct - All 8 versions

Glucocorticoid sensitivity is determined by a specific glucocorticoid receptor …

- endojournals.org
A Stevens, DW Ray, E Zeggini, S John, HL … - Journal of Clinical …, 2004 - Endocrine Soc
ENDOGENOUS GLUCOCORTICOID (GC) production mediates multiple metabolic effects and increased
production is required for a successful stress response. GCs are potent antiinflammatory drugs used
to treat conditions such as ...
Cited by 80 - Related articles - BL Direct - All 6 versions

The ER22/23EK polymorphism in the glucocorticoid receptor gene is associated …

- endojournals.org
EFC van Rossum, PG Voorhoeve, SJ te Velde, … - Journal of Clinical …, 2004 - Endocrine Soc
Glucocorticoids play an important role in determining body composition. A polymorphism of the
glucocorticoid receptor gene (in codons 22 and 23) has previously been found to be associated with
relative glucocorticoid resistance, ...
Cited by 57 - Related articles - BL Direct - All 6 versions

A psychobiological perspective on genetic determinants of hypothalamus-pituitary- …


S Wust, IS Federenko, EF Van Rossum, JW … - Ann NY Acad …, 2004 - interscience.wiley.com
Abstract: From the perspective of psychobiological stress research we present a brief overview of
findings documenting a significant impact of genetic factors on the activity of the
hypothalamus-pituitary-adrenal ...
Cited by 54 - Related articles - All 8 versions

Association studies of genetic polymorphisms in central obesity: a critical review


R Rosmond - International journal of obesity, 2003 - nature.com
During the past decade, mutations affecting liability to central obesity have been discovered at a
phenomenal rate, and despite few consistently replicated findings, a number of intriguing results
have emerged in the literature. ...
Cited by 49 - Related articles - BL Direct - All 4 versions

Two polymorphisms in the glucocorticoid receptor gene directly affect …

- endojournals.org
H Russcher, P Smit, ELT van den Akker, EFC … - Journal of Clinical …, 2005 - Endocrine Soc
Objective and Design: We examined the basis of this altered GC sensitivity by expressing GR(N363S)
and GR(ER22/23EK) in COS-1 cells and investigating their transactivating and transrepressing
capacities using a GC response ...
Cited by 48 - Related articles - BL Direct - All 7 versions

Glucocorticoid action networks and complex psychiatric and/or somatic disorders


GP Chrousos, T Kino - Stress: The International Journal on the …, 2007 - informahealthcare.com
Glucocorticoids contribute fundamentally to the maintenance of basal and stress-related homeostasis
in all higher organisms. These hormones influence a large percentage of the expressed human genome
and their effects spare almost no ...
Cited by 51 - Related articles - BL Direct - All 6 versions

Do corticosteroids damage the brain?


J Herbert, IM Goodyer, AB Grossman, MH … - Journal of …, 2006 - interscience.wiley.com
*Department of Physiology, Development and Neuroscience, and Cambridge Centre for Brain Repair,
University of Cambridge, Cambridge, UK. †Department of Psychiatry, University of Cambridge,
Cambridge, UK. ‡Department of ...
Cited by 40 - Related articles - BL Direct - All 5 versions


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