R Saxena, L Gianniny, NP Burtt, V Lyssenko, C … - Diabetes, 2006 - Am Diabetes Assoc Recently, common noncoding variants in the TCF7L2 gene were strongly associated with increased
risk of type 2 diabetes in samples from Iceland, Denmark, and the US We genotyped 13 single
nucleotide polymorphisms (SNPs) across TCF7L2 in 8,310 individuals in family-based ... Cited by 160 - Related articles - BL Direct - All 4 versions
EMD Nielsen, L Hansen, B Carstensen, SM Echwald, T … - Diabetes, 2003 - Am Diabetes Assoc The E23K polymorphism of the pancreatic β-cell ATP-sensitive K + (K ATP ) channel subunit
Kir6.2 (KCNJ11) is associated with type 2 diabetes in whites, and a recent in vitro study of the
E23K variant suggests that the association to diabetes might be explained by a slight ... Cited by 147 - Related articles - BL Direct - All 5 versions
AT Hattersley, FM Ashcroft - Diabetes, 2005 - Am Diabetes Assoc Closure of ATP-sensitive K + channels (K ATP channels) in response to metabolically generated
ATP or binding of sulfonylurea drugs stimulates insulin release from pancreatic β-cells. Heterozygous
gain-of-function mutations in the KCJN11 gene encoding the Kir6.2 subunit of this ... Cited by 138 - Related articles - BL Direct - All 10 versions
- ►oxfordjournals.org F Ashcroft, P Rorsman - Human molecular genetics, 2004 - Oxford Univ Press Type 2 diabetes mellitus is a serious metabolic disease that afflicts around 5% of the population
in Western societies and over 150 million people worldwide. It is characterized by elevation of
the blood glucose concentration, usually presents in middle age, and is exacerbated by ... Cited by 70 - Related articles - All 5 versions
- ►diabetesjournals.org JC Koster, MA Permutt, CG Nichols - Diabetes, 2005 - Am Diabetes Assoc The ATP-sensitive K + channel (K ATP channel) senses metabolic changes in the pancreatic
β-cell, thereby coupling metabolism to electrical activity and ultimately to insulin secretion. When
K ATP channels open, β-cells hyperpolarize and insulin secretion is suppressed. The ... Cited by 43 - Related articles - BL Direct - All 5 versions
J Bryan, WH Vila-Carriles, G Zhao, AP Babenko, L … - Diabetes, 2004 - Am Diabetes Assoc Advances in understanding the overall structural features of inward rectifiers and ATP-binding
cassette (ABC) transporters are providing novel insight into the architecture of ATP-sensitive
K + channels (K ATP channels) (K IR 6.0/SUR) 4 . The structure of the K IR pore has been ... Cited by 44 - Related articles - BL Direct - All 4 versions
RM Van Dam, B Hoebee, JC Seidell, MM Schaap, … - Diabet Med, 2005 - interscience.wiley.com It is also possible that your web browser is not configured or not able to display style sheets.
In this case, although the visual presentation will be degraded, the site should continue to be
functional. We recommend using the latest version of Microsoft or Mozilla web browser to ... Cited by 43 - Related articles - All 4 versions
FM Ashcroft, P Rorsman - Reviews in Endocrine & Metabolic Disorders, 2004 - Springer Key Words. pancreatic β-cells, insulin, KATP channel, MODY, diabetes ... Type-2 diabetes is
a multifactorial polygenic disease, char- acterised by elevated blood glucose levels, that usually
presents in middle age and is exacerbated by obesity. Its causes are currently unclear, ... Cited by 23 - Related articles - BL Direct - All 3 versions
S Haider, JF Antcliff, P Proks, MSP Sansom, FM … - Journal of molecular and …, 2005 - Elsevier ATP-sensitive potassium (K ATP ) channels are found in a wide variety of cell types where they
couple cell metabolism to electrical activity. In glucose-sensing tissues, these channels respond
to fluctuating changes in blood glucose concentration, but in other tissues they are ... Cited by 20 - Related articles - All 6 versions
P Proks, JD Lippiat - Current pharmaceutical design, 2006 - ingentaconnect.com Abstract: Type-2, or non-insulin-dependent diabetes mellitus is a serious disease that is now
widespread throughout Western society. Glucose intolerance, or failure of glucose to stimulate
insulin secretion, is a primary factor in the mani- festation of this disease and is likely to be ... Cited by 19 - Related articles - BL Direct - All 4 versions
