- ►unc.edu [PDF] RA Coleman, DP Lee - Progress in Lipid Research, 2004 - Elsevier Since the pathways of glycerolipid biosynthesis were elucidated in the 1950's,
considerable knowledge has been gained about the enzymes that catalyze the lipid
biosynthetic reactions and the factors that regulate triacylglycerol ... Cited by 184 - Related articles - All 8 versions
- ►ucsf.edu [PDF] SJ Stone, HM Myers, SM Watkins, BE Brown, … - Journal of Biological Chemistry, 2004 - ASBMB The synthesis of triglycerides is catalyzed by two known acyl-CoA:diacylglycerol
acyltransferase (DGAT) enzymes. Although they catalyze the same biochemical
reaction, these enzymes share no sequence homology, and their relative ... Cited by 125 - Related articles - BL Direct - All 9 versions
- ►cell.com J Phan, K Reue - Cell Metabolism, 2005 - Elsevier Lipodystrophy and obesity represent extreme and opposite ends of the adiposity
spectrum and have typically been attributed to alterations in the expression or
function of distinct sets of genes. We previously demonstrated that lipin ... Cited by 77 - Related articles - BL Direct - All 15 versions
- ►nih.gov KH Kim, L Zhao, Y Moon, C Kang, HS Sul - Proceedings of the National Academy of Sciences, 2004 - National Acad Sciences Adipocyte-specific secretory factor (ADSF)/resistin is a small cysteine-rich
protein secreted from adipose tissue that belongs to a gene family found in
inflammatory zone (FIZZ) or found in resistin-like molecule (RELM). ADSF ... Cited by 66 - Related articles - BL Direct - All 9 versions
- ►pubget.com [PDF] JA Villena, B Viollet, F Andreelli, A Kahn, S … - Diabetes, 2004 - Am Diabetes Assoc AMP-activated protein kinase (AMPK) is considered as a cellular energy sensor
that regulates glucose and lipid metabolism by phosphorylating key regulatory
enzymes. Despite the major role of adipose tissue in regulating energy ... Cited by 51 - Related articles - BL Direct - All 6 versions
- ►ahajournals.org HC Chen, RV Farese Jr - Arteriosclerosis, thrombosis, and vascular biology, 2005 - Am Heart Assoc Because the ability to make triglycerides is essential for the accumulation of
adipose tissue, inhibition of triglyceride synthesis may ameliorate obesity and
its related medical consequences. Acyl coenzyme A (CoA):diacylglycerol ... Cited by 44 - Related articles - All 6 versions
M Laplante, WT Festuccia, G Soucy, Y … - Diabetes, 2006 - Am Diabetes Assoc In this study, we aimed to establish the mechanisms whereby peroxisome
proliferator–activated receptor γ (PPARγ) agonism brings about
redistribution of fat toward subcutaneous depots and away from visceral ... Cited by 42 - Related articles - BL Direct - All 4 versions
G Boden - Current diabetes reports, 2006 - Springer Plasma free fatty acid (FFA) levels are elevated in obesity. FFA, by causing
insulin resistance in muscle, liver, and endothelial cells, contributes to the
development of type 2 diabetes mellitus (T2DM), hypertension, dyslipidemia, ... Cited by 41 - Related articles - BL Direct - All 4 versions
R Buettner, J Schölmerich, LC Bollheimer - Obesity, 2007 - nature.com Research Methods and Procedures: High-fat (HF) diet feeding can induce obesity
and metabolic disorders in rodents that resemble the human metabolic syndrome.
However, this dietary intervention is not standardized, and the HF-induced ... Cited by 40 - Related articles - All 3 versions
YH Yu, N Ginsberg - Annals of Medicine, 2004 - informahealthcare.com EC2.3.1.20), a key enzyme in triglyceride (TG) biosynthesis, not only
participates in lipid metabolism but also inŊuences metabolic pathways of other
fuel molecules. Changes in the expression and/or activity levels of DGAT ... Cited by 29 - Related articles - BL Direct - All 7 versions
