- ►jbc.org EK Kim, I Miller, S Aja, LE Landree, M Pinn, … - Journal of Biological Chemistry, 2004 - ASBMB Energy homeostasis and feeding are regulated by the central nervous system. C75,
a fatty acid synthase (FAS) inhibitor, causes weight loss and anorexia, implying
a novel central nervous system pathway(s) for sensing energy balance. AMP- ... Cited by 133 - Related articles - BL Direct - All 4 versions
TKT Lam, GJ Schwartz, L Rossetti… - Nature neuroscience, 2005 - dept.wofford.edu Energy homeostasis is maintained by multiple mechanisms that gather information
on the body's nutritional status and make appro- priate behavioral and metabolic
responses to changes in fuel avail- ability. Although it is clear that ... Cited by 119 - Related articles - All 5 versions
- ►pnas.org Z Hu, SH Cha, S Chohnan, MD Lane - Proceedings of the National Academy of Sciences, 2003 - National Acad Sciences Previous studies showed that ip administration of C75, a potent inhibitor of
fatty acid synthase (FAS), blocked fasting-induced up-regulation of orexigenic
neuropeptides and down-regulation of anorexigenic neuropeptides in the ... Cited by 102 - Related articles - BL Direct - All 10 versions
LE Landree, AL Hanlon, DW Strong, G … - Journal of Biological Chemistry, 2004 - ASBMB C75, a synthetic inhibitor of fatty acid synthase (FAS), is hypothesized to
alter the metabolism of neurons in the hypothalamus that regulate feeding
behavior to contribute to the decreased food intake and profound weight ... Cited by 65 - Related articles - BL Direct - All 5 versions
- ►physiology.org GN Wade, JE Jones - … Journal of Physiology- Regulatory, Integrative and …, 2004 - Am Physiological Soc Natural selection has linked the physiological controls of energy balance and
fertility such that reproduction is deferred during lean times, particularly in
female mammals. In this way, an energetically costly process is confined to ... Cited by 63 - Related articles - All 8 versions
S Gao, MD Lane - Proceedings of the National Academy of Sciences of …, 2003 - National Acad Sciences Intraperitoneal (ip) injection of C75, a fatty acid synthase inhibitor, causes a
rapid (≤2-h) and persistent (to at least 24-h) ≈95% decrease in food intake.
The persistent effect seems to be due to inhibition of the fasting-induced ... Cited by 52 - Related articles - BL Direct - All 10 versions
- ►diabetesjournals.org M López, CJ Lelliott, S Tovar, W Kimber, R … - Diabetes, 2006 - Am Diabetes Assoc Fatty acid metabolism in the hypothalamus has recently been shown to regulate
feeding. The selective estrogen receptor modulator tamoxifen (TMX) exerts a
potent anorectic effect. Here, we show that the anorectic effect of TMX is ... Cited by 38 - Related articles - BL Direct - All 8 versions
M Druce, SR Bloom - Current Opinion in Clinical Nutrition & Metabolic Care, 2003 - journals.lww.com Purpose of review: Obesity is a major public health problem and is associated
with significant morbidity and mortality from coronary heart disease and type 2
diabetes. The population is becoming increasingly obese, yet for ... Cited by 33 - Related articles - BL Direct - All 2 versions
S Bandyopadhyay, SK Pai, M Watabe, SC Gross … - Oncogene, 2005 - nature.com Fatty acid synthase (FAS), a key enzyme of the fatty acid biosynthetic pathway,
has been shown to be overexpressed in various types of human cancer and is,
therefore, considered to be an attractive target for anticancer therapy. ... Cited by 32 - Related articles - BL Direct - All 4 versions
