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Scholar Results 1 - 10 of about 40 citing Makhlouf: The role of autoimmunity in islet allograft destruction. (0.07 sec) 

Mixed hematopoietic chimerism allows cure of autoimmune diabetes through allogeneic …


B Nikolic, Y Takeuchi, I Leykin, Y Fudaba, RN … - Diabetes, 2004 - Am Diabetes Assoc
Bone marrow transplantation from diabetes-resistant strains with complete
replacement of the recipient immune system by the allogeneic donor has led to
tolerance to donor islets and cure of diabetes in a mouse model of type 1 ...
Cited by 56 - Related articles - BL Direct - All 4 versions

CD70 signaling is critical for CD28-independent CD8+ T cell-mediated alloimmune …

- jimmunol.org
A Yamada, AD Salama, M Sho, N Najafian, T … - The Journal of Immunology, 2005 - Am Assoc Immnol
The inability to reproducibly induce robust and durable transplant tolerance
using CD28-B7 pathway blockade is in part related to the persistence of
alloreactive effector/memory CD8 + T cells that are less dependent on this ...
Cited by 54 - Related articles - All 5 versions

Differential role of CCR2 in islet and heart allograft rejection: tissue specificity of …

- jimmunol.org
R Abdi, TK Means, T Ito, RN Smith, N Najafian … - The Journal of Immunology, 2004 - Am Assoc Immnol
Chemokines have a pivotal role in the mobilization and activation of specific
leukocyte subsets in acute allograft rejection. However, the role of specific
chemokines and chemokine receptors in islet allograft rejection has not ...
Cited by 43 - Related articles - BL Direct - All 4 versions

Clinical transplantation tolerance: Many rivers to cross

- jimmunol.org
AD Salama, KL Womer, MH Sayegh - The Journal of Immunology, 2007 - Am Assoc Immnol
Modern immunosuppressive regimens for organ transplantation have resulted in
excellent short-term results but less dramatic improvements in long-term
outcomes. Moreover, they are associated with significant deleterious ...
Cited by 39 - Related articles - All 5 versions

Depleting Anti-Cd4 Monoclonal Antibody Cures New-Onset Diabetes, Prevents Recurrent …


L Makhlouf, ST Grey, V Dong, E Csizmadia, … - Transplantation, 2004 - journals.lww.com
Background. The authors' laboratory previously demonstrated that long-term
tolerance to class I-dis- parate renal allografts in miniature swine can be in-
duced by a short course of cyclosporine A (CsA), and that this stable ...
Cited by 37 - Related articles - BL Direct - All 4 versions

Antigen-specific precursor frequency impacts T cell proliferation, differentiation, and …

- rupress.org
ML Ford, BH Koehn, ME Wagener, W Jiang, S … - Journal of Experimental Medicine, 2007 - jem.rupress.org
After a brief period of antigenic stimulation, T cells become committed to a
program of autonomous expansion and differentiation. We investigated the role of
antigen-specific T cell precursor frequency as a possible cell-extrinsic ...
Cited by 36 - Related articles - BL Direct - All 7 versions

Memory T cells in transplantation: generation, function, and potential role in rejection


AW Bingaman, DL Farber - American Journal of Transplantation, 2004 - interscience.wiley.com
The adaptive immune system is endowed with long-lived memory to recall previous
antigen encounters and respond more effectively to them. Memory immune responses
are mediated by antigen-specific memory T lymphocytes that exhibit enhanced ...
Cited by 34 - Related articles - BL Direct - All 5 versions

Different costimulatory and growth factor requirements for CD4+ and CD8+ T cell-mediated …

- jimmunol.org
MD Vu, F Amanullah, Y Li, G Demirci, MH … - The Journal of Immunology, 2004 - Am Assoc Immnol
Costimulatory signals and growth factor signals play a key role in commanding T
cell activation and T cell effector function. However, how costimulatory signals
and growth factor signals interact and integrate into the activation ...
Cited by 32 - Related articles - BL Direct - All 4 versions

Prospective and challenges of islet transplantation for the therapy of autoimmune diabetes

- ualberta.ca [PDF] 
AN Balamurugan, R Bottino, N Giannoukakis … - Pancreas, 2006 - journals.lww.com
Abstract: Pancreatic islet cell transplantation is an attractive treatment of
type 1 diabetes (T1D). The success enhanced by the Edmonton protocol has
fostered phenomenal progress in the field of clinical islet transplantation ...
Cited by 31 - Related articles - BL Direct - All 4 versions

MHC-mismatched islet allografts are vulnerable to autoimmune recognition in vivo

- jimmunol.org
TM Kupfer, ML Crawford, K Pham, RG Gill - The Journal of Immunology, 2005 - Am Assoc Immnol
When transplanted into type 1a diabetic recipients, islet allografts are subject
both to conventional allograft immunity and, presumably, to recurrent autoimmune
(islet-specific) pathogenesis. Importantly, CD4 T cells play a central role ...
Cited by 21 - Related articles - All 4 versions


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