BB Lowell, GI Shulman - Science, 2005 - sciencemag.org Type 2 diabetes is the most common metabolic disease in the world. In the United States, it is
the leading cause of blindness, end-stage renal disease, and nontraumatic loss of limb, with
associated health care costs estimated to exceed $130 billion per year (1). Of even ... Cited by 510 - Related articles - All 6 versions
- ►nih.gov S Krauss, CY Zhang, L Scorrano, LT … - Journal of Clinical …, 2003 - Am Soc Clin Investig Failure to secrete adequate amounts of insulin in response to increasing concentrations of glucose
is an important feature of type 2 diabetes. The mechanism for loss of glucose responsiveness
is unknown. Uncoupling protein 2 (UCP2), by virtue of its mitochondrial proton leak ... Cited by 193 - Related articles - BL Direct - All 11 versions
MD Brand, TC Esteves - Cell Metabolism, 2005 - Elsevier Uncoupling proteins (UCPs) have become prominent in the fields of thermogenesis, obesity,
diabetes, and free radical biology following the discovery of a family of novel UCPs and have
recently started to make an impact in the areas of degenerative, neurological, circulatory, ... Cited by 179 - Related articles - All 10 versions
- ►cell.com KA Moynihan, AA Grimm, MM Plueger, E Bernal- … - Cell Metabolism, 2005 - Elsevier Sir2 NAD-dependent deacetylases connect transcription, metabolism, and aging. Increasing
the dosage or activity of Sir2 extends life span in yeast, worms, and flies and promotes fat mobilization
and glucose production in mammalian cells. Here we show that increased dosage of ... Cited by 137 - Related articles - All 18 versions
- ►ahajournals.org Y Teshima, M Akao, SP Jones, E Marban - Circulation research, 2003 - Am Heart Assoc Uncoupling proteins (UCPs) are located in the mitochondrial inner membrane and partially dissipate
the transmembrane proton electrochemical gradient. UCP2 is expressed in various human and
rodent tissues, including the heart, where its functional role is unknown. In the present ... Cited by 127 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org H Kim, M Haluzik, Z Asghar, D Yau, JW Joseph, AM … - Diabetes, 2003 - Am Diabetes Assoc Abnormalities in insulin action are the characteristics of type 2 diabetes. Dominant-negative
muscle-specific IGF-I receptor (MKR) mice exhibit elevated lipid levels at an early age and eventually
develop type 2 diabetes. To evaluate the role of elevated lipids in the progression of the ... Cited by 110 - Related articles - BL Direct - All 4 versions
- ►biologists.org H Wang, G Kouri, CB Wollheim - Journal of cell science, 2005 - jcs.biologists.org The reduction in insulin secretory capacity and ß-cell mass observed in type 2 diabetes is thought
to be caused by glucolipotoxicity secondary to hyperglycemia and hyperlipidemia. Our aim in
this study was to elucidate the underlying molecular mechanisms. We found a strong ... Cited by 104 - Related articles - BL Direct - All 7 versions
JW Joseph, V Koshkin, MC Saleh, WI Sivitz, CY … - Journal of Biological …, 2004 - ASBMB Free fatty acid induced β-cell defects are dependent on ... Jamie W. Joseph 1 , Vasilij Koshkin
1 , Monique C. Saleh 3 , William I. Sivitz 2 , ... Chen-Yu Zhang 4 , Bradford B. Lowell 4 , Catherine
B. Chan 3 , ... 1 Departments of Medicine and Physiology University of Toronto, Ontario, ... Cited by 90 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org CB Chan, MC Saleh, V Koshkin, MB Wheeler - Diabetes, 2004 - Am Diabetes Assoc Stressors such as chronic hyperglycemia or hyperlipidemia may lead to insufficient insulin secretion
in susceptible individuals, contributing to type 2 diabetes. The molecules mediating this effect
are just beginning to be identified. Uncoupling protein (UCP)-2 may be one such negative ... Cited by 84 - Related articles - BL Direct - All 4 versions
- ►aspetjournals.org MW Fariss, CB Chan, M Patel, B Van Houten, S … - Molecular interventions, 2005 - ASPET Oxidative stress and mitochondrial oxidative damage have been implicated in the etiology of
numerous common diseases. The critical mitochondrial events responsible for oxidative
stress–mediated cell death (toxic oxidative stress), however, have yet to be defined. ... Cited by 69 - Related articles - All 2 versions
