- ►shouxi.net GS Eisenbarth, PA Gottlieb - The New England journal of medicine, 2004 - nejm.org Disease is determined by a subgroup of T cells that recognize one or more
peptides of the target organ. These peptides are bound in the groove of HLA
molecules and are presented to the T-cell receptor (TCR) of T lymphocytes. ... Cited by 192 - Related articles - BL Direct - All 16 versions
- ►jimmunol.org L Wen, J Peng, Z Li, FS Wong - The Journal of Immunology, 2004 - Am Assoc Immnol Viral infections have previously been implicated as a trigger of autoimmune
diabetes. In this study, we compared a viral mimic with other microbial
components derived from bacteria in triggering diabetes development in ... Cited by 60 - Related articles - All 4 versions
- ►asamnet.de [PDF] I Durinovic-Bello, M Schlosser, M Riedl, N … - Diabetologia, 2004 - Springer Aims/hypothesis. Preproinsulin is a target T cell auto- antigen in human Type 1
diabetes. This study analyses the phenotype and epitope recognition of
preproinsulin reactive T cells in subjects with a high genetic risk of ... Cited by 36 - Related articles - BL Direct - All 8 versions
GJ Prud'homme, R Draghia-Akli, Q Wang - Gene therapy, 2007 - nature.com Type I diabetes mellitus (T1D) is due to a loss of immune tolerance to islet
antigen and thus, there is intense interest in developing therapies that can
re-establish it. Tolerance is maintained by complex mechanisms that include ... Cited by 20 - Related articles - BL Direct - All 4 versions
- ►jimmunol.org PP Ho, P Fontoura, M Platten, RA Sobel, JJ … - The Journal of Immunology, 2005 - Am Assoc Immnol Targeting pathogenic T cells with Ag-specific tolerizing DNA vaccines encoding
autoantigens is a powerful and feasible therapeutic strategy for Th1-mediated
autoimmune diseases. However, plasmid DNA contains abundant unmethylated ... Cited by 17 - Related articles - BL Direct - All 7 versions
A Hänninen, E Hamilton-Williams, C Kurts - Annals of Medicine, 2003 - informahealthcare.com Type 1 diabetes is an immune-mediated disease typically preceded by a long
preclinical stage during which a growing number of islet-cell-specific
autoantibodies appear in the serum. Although antigen-specific T lymphocytes ... Cited by 11 - Related articles - BL Direct - All 6 versions
Y Glinka, Y Chang, GJ Prud'homme - Molecular Therapy, 2006 - Elsevier DNA vaccination of autoimmune diabetes-prone NOD mice with unmodified target
islet antigens, ie, preproinsulin (PPIns) or glutamic acid decarboxylase 65
(GAD65), is poorly protective. However, in this study, we demonstrate ... Cited by 10 - Related articles - All 4 versions
A Gauvrit, M Debailleul, AT Vu, P Sai, JM … - Clinical and Experimental Immunology, 2004 - pubmedcentral.nih.gov DNA vaccination encoding β cell autoantigens has been shown very recently to
prevent type I diabetes in non-obese diabetic (NOD) mice. However, DNA
vaccination encoding microbial or reporter antigens is known to induce ... Cited by 10 - Related articles - BL Direct - All 5 versions
AF Li, J Hough, D Henderson, A Escher - Vaccine, 2004 - Elsevier Genetic vaccines encoding pancreatic beta cell antigens can prevent autoimmune
(type 1) diabetes when delivered into murine model systems, but there is a need
to improve their efficacy. Here, we investigated the effects of ... Cited by 10 - Related articles - All 3 versions
- ►diabetesjournals.org C Haase, K Skak, BK Michelsen, H Markholst - Diabetes, 2004 - Am Diabetes Assoc The initial events leading to activation of the immune system in type 1 diabetes
are still largely unknown. In vivo, dendritic cells (DCs) are thought to be the
only antigen-presenting cells (APCs) capable of activating naïve T-cells ... Cited by 8 - Related articles - BL Direct - All 4 versions
