- ►jimmunol.org D Zipris, E Lien, JX Xie, DL Greiner, JP … - The Journal of …, 2005 - Am Assoc Immnol Virus infection is hypothesized to be an important environmental "trigger" of type 1 diabetes in
humans. We used the BBDR rat model to investigate the relationship between viral infection
and autoimmune diabetes. BBDR rats are diabetes-free in viral Ab-free housing, but the ... Cited by 61 - Related articles - All 5 versions
- ►nih.gov M Pandarpurkar, L Wilson-Fritch, S … - Proceedings of the …, 2003 - National Acad Sciences Apoptosis is a regulated cell death program controlled by extrinsic and intrinsic signaling
pathways. The intrinsic pathway involves stress signals that activate pro-apoptotic members
of the Bcl-2 family, inducing permeabilization of mitochondria and release of apoptogenic ... Cited by 48 - Related articles - BL Direct - All 11 versions
- ►nas.edu [PDF] JP Mordes, P Poussier, AR Rossini, EP … - Animal Models of … - books.google.com 2 Animal Models of Diabetes BBDR Rats and Translational Modeling Fidelity 19 Immunological
Perturbation and Diabetes Induction in Other Rat Strains 20 TLRLigation 20 Viral Infection 21
A Working Hypothesis of Autoimmune Diabetes in the Rat 21 What Does Autoimmune ... Cited by 43 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org AA Rossini - Diabetes, 2004 - Am Diabetes Assoc The concept of immunological tolerance is central to our understanding of type 1 diabetes and
the development of strategies for its prediction, prevention, and cure. Tolerance simply refers
to the absence of an immune response. Most of us are born with an immune system that ... Cited by 27 - Related articles - BL Direct - All 10 versions
- ►jimmunol.org DJ Todd, EM Forsberg, DL Greiner, JP … - The Journal of …, 2004 - Am Assoc Immnol Defects in the intestinal immune system may contribute to the pathogenesis of autoimmune
diseases. Intraepithelial lymphocytes represent a substantial fraction of gut-associated
lymphocytes, but their function in mucosal immunity is unclear. A newly described ... Cited by 22 - Related articles - BL Direct - All 6 versions
- ►jimmunol.org MJ Hessner, X Wang, L Meyer, R Geoffrey, S … - The Journal of …, 2004 - Am Assoc Immnol Allergy and autoimmunity are both examples of deregulated immunity characterized by inflammation
and injury of targeted tissues that have until recently been considered disparate disease
processes. However, recent findings have implicated mast cells, in coordination with ... Cited by 16 - Related articles - BL Direct - All 7 versions
- ►diabetesjournals.org EP Blankenhorn, L Rodemich, C Martin-Fernandez, J … - Diabetes, 2005 - Am Diabetes Assoc BBDR rats develop autoimmune diabetes only after challenge with environmental
perturbants. These perturbants include polyinosinic:polycytidylic acid (poly I:C, a ligand of
toll-like receptor 3), agents that deplete regulatory T-cell (Treg) populations, and a non–β- ... Cited by 12 - Related articles - All 6 versions
JP Mordes, DL Guberski, JH Leif, BA Woda, JF … - Diabetes, 2005 - Am Diabetes Assoc We describe a new rat model of autoimmune diabetes that arose in a major histocompatibility
complex congenic LEW rat. Spontaneous diabetes in LEW.1WR1 rats (RT1 u/u/a ) occurs with
a cumulative frequency of ∼2% at a median age of 59 days. The disease is characterized ... Cited by 10 - Related articles - BL Direct - All 6 versions
JM Fuller, AE Kwitek, TJ Hawkins, DH Moralejo, W Lu, … - Diabetes, 2006 - Am Diabetes Assoc Failure to express the Gimap5 protein is associated with lymphopenia (lyp) and linked to spontaneous
diabetes in the diabetes-prone BioBreeding (BBDP) rat. Gimap5 is a member of seven related
genes located within 150 Kb on rat chromosome 4. Congenic DR. lyp/lyp rats, where ... Cited by 6 - Related articles - BL Direct - All 5 versions
L Cousins, M Graham, R Tooze, C Carter, JR Miller, FM … - Gastroenterology, 2006 - Elsevier To analyze the role of the lyp gene separately from other BB genetic factors, we created congenic
rats in which the BB lyp gene was backcrossed onto the PVG-RT1 u strain. 11 The PVG-RT1
u , lyp/lyp rat did not develop diabetes but unexpectedly developed intestinal ... Cited by 5 - Related articles - All 14 versions
