- ►ahajournals.org A Goldin, JA Beckman, AM Schmidt, MA … - Circulation, 2006 - Am Heart Assoc Advanced glycation end products (AGEs) are proteins or lipids that become
glycated after exposure to sugars. AGEs are prevalent in the diabetic
vasculature and contribute to the development of atherosclerosis. The ... Cited by 182 - Related articles - All 7 versions
- ►asnjournals.org T Wendt, N Tanji, J Guo, BI Hudson, A … - Journal of the American Society of Nephrology, 2003 - Am Soc Nephrol Irrespective of the underlying mechanisms, elevated levels of blood glucose
ignite a vicious cycle of metabolic disturbances within the intracellular and
extracellular environment that, if left unchecked, lead to a broad array of ... Cited by 137 - Related articles - BL Direct - All 6 versions
PJ Thornalley - Archives of Biochemistry and Biophysics, 2003 - Elsevier Aminoguanidine (AG) is a prototype therapeutic agent for the prevention of
formation of advanced glycation endproducts. It reacts rapidly with
α,β-dicarbonyl compounds such as methylglyoxal, glyoxal, and ... Cited by 123 - Related articles - All 4 versions
- ►endojournals.org BF Schrijvers, AS De Vriese, A Flyvbjerg - Endocrine reviews, 2004 - Endocrine Soc At present, diabetic kidney disease affects about 15–25% of type 1 and
30–40% of type 2 diabetic patients. Several decades of extensive research has
elucidated various pathways to be implicated in the development of diabetic ... Cited by 119 - Related articles - All 5 versions
- ►asnjournals.org M Nangaku, T Miyata, T Sada, M Mizuno, R … - Journal of the American Society of Nephrology, 2003 - Am Soc Nephrol In the present study, we use a strain of a spontaneously
hypertensive/NIH-corpulent rat [SHR/NDmc-cp (fat/fat)] as a model of type 2 DN
(6) to unravel the mechanisms of the ARB-induced renoprotection against DN. ... Cited by 94 - Related articles - BL Direct - All 6 versions
- ►amjpathol.org G Zhou, C Li, L Cai - American Journal of Pathology, 2004 - ASIP Advanced glycation end-products (AGEs) play a critical role in diabetic
nephropathy by stimulating extracellular matrix (ECM) synthesis. Connective
tissue growth factor (CTGF) is a potent inducer of ECM synthesis and ... Cited by 77 - Related articles - BL Direct - All 4 versions
- ►cell.com RM Carey, HM Siragy - Trends in Endocrinology & Metabolism, 2003 - Elsevier The renin–angiotensin system (RAS) is a coordinated cascade of proteins and
peptide hormones, the principal effector of which is angiotensin II (ANG II).
Evidence now indicates that the kidney regulates its function via a self- ... Cited by 70 - Related articles - All 11 versions
ML Caramori, M Mauer - Current opinion in nephrology and hypertension, 2003 - journals.lww.com Recent findings: There have been advances in the understanding of diabetic
nephropathy pathology. Clearly, structural changes may be advanced before any
clinical findings are apparent. Not all functional consequences of the ... Cited by 68 - Related articles - BL Direct - All 7 versions
- ►cell.com G Giacchetti, LA Sechi, S Rilli, RM Carey - Trends in Endocrinology & Metabolism, 2005 - Elsevier In diabetes mellitus (DM), the circulating renin–angiotensin system (RAS) is
suppressed, but the renal tissue RAS is activated. Hyperglycemia increases
tissue angiotensin II (Ang II), which induces oxidative stress, endothelial ... Cited by 68 - Related articles - All 6 versions
VM Monnier - Archives of Biochemistry and Biophysics, 2003 - Elsevier The field of Maillard/glycation reactions in vivo has grown enormously during
the past 20 years, going from 25 to 500 publications per year. It is now well
recognized that many of the “advanced” products form oxidatively or ... Cited by 57 - Related articles - All 5 versions
