BB Lowell, GI Shulman - Science, 2005 - sciencemag.org Type 2 diabetes is the most common metabolic disease in the world. In the United States, it is
the leading cause of blindness, end-stage renal disease, and nontraumatic loss of limb, with
associated health care costs estimated to exceed $130 billion per year (1). Of even ... Cited by 510 - Related articles - All 6 versions
G Sesti, M Cardellini, MA Marini, S Frontoni, MD'Adamo … - Diabetes, 2003 - Am Diabetes Assoc It was reported that the common −866G/A polymorphism in the promoter of the human uncoupling
protein-2 (UCP2) gene, which enhances its trascriptional activity, is associated with increased
mRNA levels in human adipocytes and reduced risk of obesity. Studies in knockout mice ... Cited by 87 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org CB Chan, MC Saleh, V Koshkin, MB Wheeler - Diabetes, 2004 - Am Diabetes Assoc Stressors such as chronic hyperglycemia or hyperlipidemia may lead to insufficient insulin secretion
in susceptible individuals, contributing to type 2 diabetes. The molecules mediating this effect
are just beginning to be identified. Uncoupling protein (UCP)-2 may be one such negative ... Cited by 84 - Related articles - BL Direct - All 4 versions
- ►aspetjournals.org MW Fariss, CB Chan, M Patel, B Van Houten, S … - Molecular interventions, 2005 - ASPET Oxidative stress and mitochondrial oxidative damage have been implicated in the etiology of
numerous common diseases. The critical mitochondrial events responsible for oxidative
stress–mediated cell death (toxic oxidative stress), however, have yet to be defined. ... Cited by 69 - Related articles - All 2 versions
- ►oxfordjournals.org F Ashcroft, P Rorsman - Human molecular genetics, 2004 - Oxford Univ Press Type 2 diabetes mellitus is a serious metabolic disease that afflicts around 5% of the population
in Western societies and over 150 million people worldwide. It is characterized by elevation of
the blood glucose concentration, usually presents in middle age, and is exacerbated by ... Cited by 70 - Related articles - All 5 versions
MJ Gunter, MF Leitzmann - The Journal of nutritional biochemistry, 2006 - Elsevier There is increasing evidence that dysregulation of energy homeostasis is associated with colorectal
carcinogenesis. Epidemiological data have consistently demonstrated a positive relation between
increased body size and colorectal malignancy, whereas mechanistic studies have ... Cited by 65 - Related articles - All 8 versions
- ►diabetesjournals.org H Oberkofler, V Linnemayr, R Weitgasser, K Klein, M … - Diabetes, 2004 - Am Diabetes Assoc Peroxisome proliferator–activated receptor coactivator-1α (PGC-1α) is a transcriptional coactivator
implicated in transcriptional programs of hepatic gluconeogenesis, oxidative
phosphorylation, and insulin release by β-cells. To study associations of the PGC-1α ... Cited by 65 - Related articles - BL Direct - All 4 versions
- ►physiology.org H Wang, WS Chu, T Lu, SJ Hasstedt, PA … - American Journal of …, 2004 - Am Physiological Soc The onset of type 2 diabetes (T2DM) is preceded by obesity, insulin resistance, and impaired
-cell function. Uncoupling protein-2 (UCP2) is a widely expressed inner mitochondrial membrane
protein. Common polymorphisms of the UCP2 gene have been implicated in diabetes, in ... Cited by 63 - Related articles - BL Direct - All 5 versions
MD'Adamo, L Perego, M Cardellini, MA Marini, S … - Diabetes, 2004 - Am Diabetes Assoc Uncoupling protein (UCP)-2 is a member of the mitochondrial inner membrane carriers that uncouple
pro-ton entry in the mitochondrial matrix from ATP synthesis. The −866G/A polymorphism in the
UCP2 gene, which enhances its transcriptional activity, was associated with enhanced ... Cited by 64 - Related articles - BL Direct - All 5 versions
V Lyssenko, P Almgren, D Anevski, M Orho- … - PLoS …, 2005 - medicine.plosjournals.org By using a Cox proportional hazard model, common variants in the PPARG (P12A), CAPN10
(SNP43 and 44), KCNJ11 (E23K), UCP2 (−866G>A), and IRS1 (G972R) genes were studied
for their ability to predict T2D in 2,293 individuals participating in the Botnia study in ... Cited by 63 - Related articles - Cached - BL Direct - All 10 versions
