P Dandona, A Aljada, A Bandyopadhyay - TRENDS in Immunology, 2004 - Elsevier Recent data have revealed that the plasma concentration of inflammatory
mediators, such as tumour necrosis factor-α (TNF-α) and interleukin-6 (IL-6),
is increased in the insulin resistant states of obesity and type 2 ... Cited by 528 - Related articles - All 4 versions
- ►endojournals.org JM Fernandez-Real, W Ricart - Endocrine Reviews, 2003 - Endocrine Soc Insulin resistance is increasingly recognized as a chronic, low-level,
inflammatory state. Hyperinsulinemia and insulin action were initially proposed
as the common preceding factors of hypertension, low high-density ... Cited by 430 - Related articles - BL Direct - All 5 versions
M Fasshauer, S Kralisch, M Klier, U Lossner, … - Biochemical and Biophysical Research …, 2003 - Elsevier Recently, it has been shown that adiponectin is an important insulin-sensitizing
fat-derived protein which is downregulated in insulin resistance and obesity,
and replenishment of which improves insulin sensitivity. In contrast, ... Cited by 292 - Related articles - BL Direct - All 4 versions
M Fasshauer, R Paschke - Diabetologia, 2003 - Springer It has long been known that obesity and insulin resis- tance are linked.
Recently, it has been shown that adi- pocytes secrete several proteins including
tumour ne- crosis factor-α, interleukin-6, resistin, and adiponec- tin. ... Cited by 287 - Related articles - BL Direct - All 4 versions
JJ Senn, PJ Klover, IA Nowak, TA Zimmers, … - Journal of Biological Chemistry, 2003 - ASBMB Interleukin-6 (IL-6) is one of several pro-inflammatory cytokines implicated in
insulin resistance during infection, cachexia, and obesity. We recently
demonstrated that IL-6 inhibits insulin signaling in hepatocytes (Senn, JJ, ... Cited by 273 - Related articles - BL Direct - All 9 versions
- ►jbc.org V Rotter, I Nagaev, U Smith - Journal of Biological Chemistry, 2003 - ASBMB Several studies have shown a relationship between interleukin (IL) 6 levels and
insulin resistance. We here show that human subcutaneous adipose cells, like
3T3-L1 cells, are target cells for IL-6. To examine putative mechanisms and ... Cited by 276 - Related articles - BL Direct - All 5 versions
- ►alfediam.org [PDF] M Guerre-Millo - Diabetes and Metabolism, 2004 - Elsevier It is now recognized that the white adipose tissue (WAT) produces a variety of
bioactive peptides, collectively termed “adipokines”. Alteration of WAT mass
in obesity or lipoatrophy, affects the production of most adipose secreted ... Cited by 169 - Related articles - BL Direct - All 10 versions
I Juhan-Vague, MC Alessi, A Mavri, PE … - Journal of Thrombosis and Haemostasis, 2003 - interscience.wiley.com Summary. Elevated plasma plasminogen activator inhibitor-1 (PAI-1) level is a
core feature of insulin-resistance syndrome (IRS). Atherothrombotic
complications in IRS are partly attributed to impaired fibrinolysis caused ... Cited by 169 - Related articles - BL Direct - All 3 versions
E Bugianesi, AJ McCullough, G Marchesini… - Hepatology, 2005 - interscience.wiley.com Insulin resistance (IR) is the pathophysiological hallmark of nonalcoholic fatty
liver disease (NAFLD), one of the most common causes of chronic liver disease in
Western countries. We review the definition of IR, the methods for the ... Cited by 169 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org HJ Kim, T Higashimori, SY Park, H Choi, J … - Diabetes, 2004 - Am Diabetes Assoc The circulating level of the inflammatory cytokine interleukin (IL)-6 is
elevated in various insulin-resistant states including type 2 diabetes, obesity,
cancer, and HIV-associated lipodystrophy. To determine the role of IL-6 in ... Cited by 164 - Related articles - BL Direct - All 4 versions
