- ►nih.gov KI Rother, DM Harlan - Journal of Clinical Investigation, 2004 - Am Soc Clin Investig Worldwide, more than 750 individuals with type 1 diabetes mellitus (T1DM) have
received allogeneic islet transplants since 1974, in an effort to cure their
chronic condition. Though this is still a small number (especially when ... Cited by 103 - Related articles - BL Direct - All 11 versions
- ►endojournals.org DJ Drucker - Endocrinology, 2003 - Endocrine Soc Studies of the natural history of type 2 diabetes inform us that a progressive
decline in ß-cell function is common in diabetic patients independent of the
method of treatment (2). Hence, new approaches are clearly needed that not ... Cited by 101 - Related articles - BL Direct - All 4 versions
M Narushima, N Kobayashi, T Okitsu, Y Tanaka … - Nature biotechnology, 2005 - journals2005.pasteur.ac.ir A human pancreatic b-cell line that is functionally equivalent to primary
b-cells has not been available. We established a reversibly immortalized human
b-cell clone (NAKT-15) by transfection of primary human b-cells with a ... Cited by 71 - Related articles - BL Direct - All 6 versions
A Lechner, AL Nolan, RA Blacken, JF … - Biochemical and Biophysical Research …, 2005 - Elsevier Cellular replacement therapy holds promise for the treatment of diabetes
mellitus but donor tissue is severely limited. Therefore, we investigated
whether insulin-secreting cells could be differentiated in vitro from a ... Cited by 60 - Related articles - All 4 versions
L Ouziel-Yahalom, M Zalzman, L Anker-Kitai, S … - Biochemical and Biophysical Research …, 2006 - Elsevier Type 1 diabetes is caused by autoimmune destruction of the pancreatic islet
insulin-producing β cells. Insulin administration does not prevent long-term
complications of the disease, since the optimal insulin dosage is difficult ... Cited by 52 - Related articles - All 4 versions
- ►sciencemag.org K Shchors, E Shchors, F Rostker, ER Lawlor, … - Genes & development, 2006 - genesdev.cshlp.org Although induction of blood vessel growth is acknowledged as a pivotal
requirement for the evolution of macroscopic tumors, the events that trigger
onset of tumor angiogenesis remain largely obscure. The pervasive Myc ... Cited by 39 - Related articles - BL Direct - All 14 versions
G Parnaud, D Bosco, T Berney, F Pattou, J … - Diabetologia, 2008 - Springer Abstract Aims/hypothesis The aim of the study was to determine whether purified
beta cells can replicate in vitro and whether this is enhanced by extracellular
matrix (ECM) and growth factors. Methods Human beta cells were purified by ... Cited by 38 - Related articles - BL Direct - All 3 versions
- ►shouxi.net N Weinberg, L Ouziel-Yahalom, S Knoller, S … - Diabetes, 2007 - Am Diabetes Assoc Understanding and manipulating pancreatic β-cell proliferation is a major
challenge for pancreas biology and diabetes therapy. Recent studies have raised
the possibility that human β-cells can undergo dedifferentiation and give ... Cited by 36 - Related articles - BL Direct - All 5 versions
- ►ucla.edu [PDF] JJ MEIER, A BHUSHAN, PC BUTLER - Pediatric research, 2006 - journals.lww.com Both type 1 and type 2 diabetes are characterized by a marked deficit in
beta-cell mass causing insufficient insulin secretion. Beta-cell replacement
strategies may eventually provide a cure for diabetes. Current therapeutic ... Cited by 32 - Related articles - BL Direct - All 7 versions
