- ►physiology.org S Seino, T Shibasaki - Physiological reviews, 2005 - Am Physiological Soc Stimulus-secretion coupling is an essential process in secretory cells in which
regulated exocytosis occurs, including neuronal, neuroendocrine, endocrine, and
exocrine cells. While an increase in intracellular Ca 2+ concentration ([Ca ... Cited by 143 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org GG Holz - Diabetes, 2004 - Am Diabetes Assoc Recently published studies of islet cell function reveal unexpected features of
glucagon-like peptide-1 (GLP-1) receptor-mediated signal transduction in the
pancreatic β-cell. Although GLP-1 is established to be a cAMP-elevating ... Cited by 127 - Related articles - BL Direct - All 6 versions
- ►rupress.org L Eliasson, X Ma, E Renstrom, S Barg, PO … - Journal of General Physiology, 2003 - jgp.rupress.org Measurements of membrane capacitance were applied to dissect the cellular
mechanisms underlying PKA-dependent and -independent stimulation of insulin
secretion by cyclic AMP. Whereas the PKA-independent ... Cited by 112 - Related articles - BL Direct - All 5 versions
- ►physiology.org JJ Holst - Physiological reviews, 2007 - Am Physiological Soc Glucagon-like peptide 1 (GLP-1) is a 30-amino acid peptide hormone produced in
the intestinal epithelial endocrine L-cells by differential processing of
proglucagon, the gene which is expressed in these cells. The current ... Cited by 113 - Related articles - BL Direct - All 5 versions
FM Gribble, F Reimann - Diabetologia, 2003 - Springer Hypoglycaemic agents such as sulphonylureas and the newer group of
“glinides” stimulate insulin secretion by closing ATP-sensitive potassium (K
ATP ) channels in pancreatic beta cells, but have varying cross-reac- ... Cited by 106 - Related articles - BL Direct - All 3 versions
- ►nih.gov GG Holz, G Kang, M Harbeck, MW Roe, OG … - The Journal of Physiology, 2006 - Physiological Soc Epac is an acronym for the exchange proteins activated directly by cyclic AMP, a
family of cAMP-regulated guanine nucleotide exchange factors (cAMPGEFs) that
mediate protein kinase A (PKA)-independent signal transduction properties ... Cited by 64 - Related articles - BL Direct - All 32 versions
- ►shouxi.net G Kang, OG Chepurny, MJ Rindler, L Collis, … - The Journal of Physiology, 2005 - Physiological Soc The blood glucose-lowering hormone glucagon-like peptide-1 (GLP-1) stimulates
cAMP production, promotes Ca 2+ influx, and mobilizes an intracellular source of
Ca 2+ in pancreatic β cells. Here we provide evidence that these actions ... Cited by 51 - Related articles - All 18 versions
- ►jbc.org M Nenquin, A Szollosi, L Aguilar-Bryan, J … - Journal of Biological Chemistry, 2004 - ASBMB In normal -cells glucose induces insulin secretion by activating both a
triggering pathway (closure of K ATP channels, depolarization, and rise in
cytosolic [Ca 2+ ] i ) and an amplifying pathway (augmentation of Ca 2+ ... Cited by 44 - Related articles - BL Direct - All 5 versions
- ►physoc.org G Kang, OG Chepurny, B Malester, MJ … - The Journal of Physiology, 2006 - Physiological Soc The Epac family of cAMP-regulated guanine nucleotide exchange factors (cAMPGEFs,
also known as Epac1 and Epac2) mediate stimulatory actions of the second
messenger cAMP on insulin secretion from pancreatic β cells. Because Epac2 ... Cited by 38 - Related articles - BL Direct - All 19 versions
- ►nyumed.org [PDF] G Holz - Hormone and Metabolic Research, 2004 - thieme-connect.com The GLP-1 receptor is a Class B heptahelical G-protein-coupled receptor that
stimulates cAMP production in pancreatic ?-cells. GLP-1 utilizes this receptor
to activate two distinct classes of cAMP-binding proteins: protein kinase A ... Cited by 38 - Related articles - All 32 versions
