NE Zachara, GW Hart - BBA-General Subjects, 2004 - Elsevier Myriad nuclear and cytoplasmic proteins in metazoans are modified on Ser and Thr
residues by the monosaccharide O-linked β-N-acetylglucosamine (O-GlcNAc). The
rapid and dynamic change in O-GlcNAc levels in response to extracellular ... Cited by 106 - Related articles - All 5 versions
NE Zachara, N O'Donnell, WD Cheung, JJ … - Journal of Biological Chemistry, 2004 - ASBMB Cellular response to environmental, physiological, or chemical stress is key to
survival following injury or disease. Here we describe a unique signaling
mechanism by which cells detect and respond to stress in order to survive. ... Cited by 103 - Related articles - BL Direct - All 4 versions
NE Zachara, GW Hart - BBA-Molecular and Cell Biology of Lipids, 2006 - Elsevier An increasing body of evidence points to a central regulatory role for glucose
in mediating cellular processes and expands the role of glucose well beyond its
traditional role(s) in energy metabolism. Recently, it has been recognized ... Cited by 78 - Related articles - All 4 versions
J Liu, Y Pang, T Chang, P Bounelis, JC … - Journal of molecular and cellular cardiology, 2006 - Elsevier Increased hexosamine biosynthesis pathway (HBP) flux and elevated levels of
protein O-linked-N-acetylglucosamine (O-GlcNAc) decrease calcium influx into
isolated cardiomyocytes. Increased O-GlcNAc levels also increase tolerance ... Cited by 36 - Related articles - All 7 versions
- ►cardiovascres.org N Fulop, RB Marchase, JC Chatham - Cardiovascular research, 2007 - cardiovascres.org There is growing recognition that the O-linked attachment of
N-acetyl-glucosamine (O-GlcNAc) on serine and threonine residues of nuclear and
cytoplasmic proteins is a highly dynamic post-translational modification ... Cited by 36 - Related articles - All 7 versions
- ►physiology.org T Nagy, V Champattanachai, RB Marchase, … - American Journal of Physiology- Cell Physiology, 2006 - Am Physiological Soc We previously reported that glucosamine and hyperglycemia attenuate the response
of cardiomyocytes to inositol 1,4,5-trisphosphate-generating agonists such as
ANG II. This appears to be related to an increase in flux through the ... Cited by 30 - Related articles - BL Direct - All 3 versions
Y Pang, P Bounelis, JC Chatham, RB … - Diabetes, 2004 - Am Diabetes Assoc Hyperglycemia diminishes positive inotropic responses to agonists that activate
phospholipase C (PLC) and generate inositol trisphosphate (1,4,5). The
mechanisms underlying both the inotropic responses and hyperglycemia's ... Cited by 27 - Related articles - BL Direct - All 4 versions
L Cai - Free Radical Biology and Medicine, 2006 - Elsevier Diabetic cardiomyopathy has become a major contributor to the increased
mortality of diabetic patients. Although the development and progression of
diabetic cardiomyopathy are considered to be associated with ... Cited by 22 - Related articles - All 6 versions
- ►physiology.org VP Singh, B Le, VB Bhat, KM Baker, R Kumar - American Journal of Physiology- Heart and Circulatory …, 2007 - Am Physiological Soc The prevailing paradigm is that cardiac ANG II is synthesized in the
extracellular space from components of the circulating and/or local
renin-angiotensin system. The recent discovery of intracrine effects of ANG ... Cited by 22 - Related articles - BL Direct - All 6 versions
- ►ahajournals.org SP Jones, NE Zachara, GA Ngoh, BG Hill, Y … - Circulation, 2008 - Am Heart Assoc Methods and Results— In mouse hearts subjected to in vivo ischemic
preconditioning, O-GlcNAc levels were significantly elevated. Pharmacological
augmentation of O-GlcNAc levels in vivo was sufficient to reduce myocardial ... Cited by 21 - Related articles - All 6 versions
