L Zheng, C Szabó, TS Kern - Diabetes, 2004 - Am Diabetes Assoc The current study investigated the role of poly(ADP-ribose) polymerase (PARP) in
the development of diabetic retinopathy. Activity of PARP was increased in whole
retina and in endothelial cells and pericytes of diabetic rats. ... Cited by 98 - Related articles - BL Direct - All 5 versions
C Gerhardinger, MB Costa, MC Coulombe, I … - Investigative ophthalmology & visual science, 2005 - ARVO RESULTS. Gene expression profiling identified 78 genes as differentially
expressed in diabetic Müller cells. One third of these genes were associated
with inflammation, including a large cluster (18% of the differentially ... Cited by 75 - Related articles - All 6 versions
DA Antonetti, AJ Barber, SK Bronson, WM … - Diabetes, 2006 - Am Diabetes Assoc Diabetic retinopathy remains a frightening prospect to patients and frustrates
physicians. Destruction of damaged retina by photocoagulation remains the
primary treatment nearly 50 years after its introduction. The diabetes ... Cited by 73 - Related articles - BL Direct - All 9 versions
Z Dagher, YS Park, V Asnaghi, T Hoehn, C … - Diabetes, 2004 - Am Diabetes Assoc The polyol (sorbitol) pathway of glucose metabolism is activated in many cell
types when intracellular glucose concentrations are high, and it can generate
cellular stress through several mechanisms. The role of the polyol pathway ... Cited by 65 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org W Sun, PJ Oates, JB Coutcher, C … - Diabetes, 2006 - Am Diabetes Assoc Previously studied inhibitors of aldose reductase were largely from two chemical
classes, spirosuccinamide/hydantoins and carboxylic acids. Each class has its
own drawbacks regarding selectivity, in vivo potency, and human safety; as ... Cited by 38 - Related articles - BL Direct - All 7 versions
X Qin, A Goldfine, N Krumrei, L Grubissich, J … - Diabetes, 2004 - Am Diabetes Assoc Micro- and macrovascular diseases are major causes of morbidity and mortality in
the diabetic population, but the cellular and molecular mechanisms that link
hyperglycemia to these complications remain incompletely understood. We ... Cited by 38 - Related articles - BL Direct - All 4 versions
SSM Chung, SK Chung - Current Drug Targets, 2005 - ingentaconnect.com Abstract: Most long-term diabetic patients develop microvascular diseases such
as retinopathy, nephropathy and neuropathy. Although tight control of blood
glucose greatly reduces the incidence of these complications, a significant ... Cited by 38 - Related articles - All 2 versions
R Simo, E Carrasco, M Garcia-Ramirez, C … - Current Diabetes Reviews, 2006 - ingentaconnect.com Abstract: Diabetic retinopathy continues to be the leading cause of legal
blindness among working-age individuals. The earliest histological features of
diabetic retinopathy include neuroretinal damage, capillary basement ... Cited by 36 - Related articles - BL Direct - All 2 versions
TS Kern - Exp Diabetes Res, 2007 - hindawi.com Diabetes causes metabolic and physiologic abnormalities in the retina, and these
changes suggest a role for inflammation in the development of diabetic
retinopathy. These changes include upregulation of iNOS, COX-2, ICAM-1, ... Cited by 34 - Related articles - View as HTML - All 12 versions
