- ►rockefeller.edu [PDF] JS Flier - Cell, 2004 - Elsevier The past ten years have been the golden age of obesity research. While long understood that
the amount of body weight and fat are determined by an interplay of inheritance and
environment, we are for the first time learning the identity of some of the responsible ... Cited by 498 - Related articles - All 27 versions
H Parikh, L Groop - Reviews in Endocrine & Metabolic Disorders, 2004 - Springer About 150 million people suffer from type 2 diabetes in the world today and it has been predicted
that this num- ber will be doubled within 15 years [1]. It is no longer a disease of the elderly, age
at onset has decreased with the epidemic increase in prevalence. There are large eth- nic ... Cited by 62 - Related articles - BL Direct - All 3 versions
X Yang, S Enerbäck, U Smith - Obesity, 2003 - nature.com Results: The expression of FOXC2, MASK, MAP3K5, retinoblastoma protein (pRb), peroxisome
proliferator-activated protein gamma (PPAR ), and retinoid X receptor gamma (RXR ) was decreased
in the insulin-resistant compared with insulin-sensitive subjects, whereas PPAR -2 and ... Cited by 53 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org L Ma, PA Tataranni, RL Hanson, AM Infante, S Kobes, … - Diabetes, 2005 - Am Diabetes Assoc Peptide YY (PYY) and Y2 receptor (Y2R) may be important in the central regulation of body weight
and food intake. To determine whether genetic variation in PYY and/or Y2R may contribute to
morbid obesity in humans, these genes were sequenced in 83 extremely obese Pima ... Cited by 37 - Related articles - All 7 versions
RL Pollex, RA Hegele - Nature Clinical Practice Cardiovascular Medicine, 2006 - nature.com Robert A Hegele is a professor of medicine and biochemistry at the Schulich School of Medicine
and Dentistry, University of Western Ontario, London, ON, Canada, and is the Director of the
Blackburn Cardiovascular Genetics Laboratory at Robarts Research Institute, London, ... Cited by 38 - Related articles - All 3 versions
- ►jlr.org T Tanoli, P Yue, D Yablonskiy, G Schonfeld - The Journal of Lipid Research, 2004 - ASBMB Fatty liver is frequent in the apolipoprotein B (apoB)-defective genetic form of familial hypobetalipoproteinemia
(FHBL), but interindividual variability in liver fat is large. To explain this, we assessed the roles
of metabolic factors in 32 affected family members with apoB-defective FHBL and 33 ... Cited by 27 - Related articles - BL Direct - All 7 versions
R McPherson, PH Jones - Current Opinion in Lipidology, 2003 - journals.lww.com Much of the increased coronary heart disease risk in obese individuals [1] is mediated by an
increased prevalence of type 2 diabetes mellitus (T2DM), hypertension, elevated plasma triglycerides
and low HDL cholesterol [2] . T2DM is characterized by progressive resistance to the ... Cited by 23 - Related articles - BL Direct - All 2 versions
P Kovacs, A Lehn-Stefan, M Stumvoll, C Bogardus, LJ … - Diabetes, 2003 - Am Diabetes Assoc FOXC2 is a winged helix gene that has been shown to counteract obesity,
hypertriglyceridemia, and diet-induced insulin resistance in rodents. Therefore, FOXC2 was analyzed
as a candidate gene for susceptibility to type 2 diabetes in Pima Indians. Four variants ... Cited by 21 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org LE Johansson, J Hoffstedt, H Parikh, E Carlsson, M … - Diabetes, 2006 - Am Diabetes Assoc Adiponutrin is one of three recently identified adipocyte lipases. Surprisingly, these proteins also
retain transacylase activity, a hitherto unknown pathway of triacylglycerol synthesis in the
adipocytes. This may enable them to participate in both anabolic and catabolic ... Cited by 21 - Related articles - BL Direct - All 6 versions
- ►ahajournals.org H Fujita, M Kang, M Eren, LA Gleaves, DE … - Circulation …, 2006 - Am Heart Assoc Elevated plasma levels of plasminogen activator inhibitor type I (PAI-1), a significant risk factor
of ischemic heart disease, are associated with insulin resistance in which insulin and transforming
growth factor (TGF)-ß play a pivotal role in regulating PAI-1 production. Forkhead ... Cited by 14 - Related articles - All 7 versions
