- ►rockefeller.edu [PDF] JS Flier - Cell, 2004 - Elsevier The past ten years have been the golden age of obesity research. While long understood that
the amount of body weight and fat are determined by an interplay of inheritance and
environment, we are for the first time learning the identity of some of the responsible ... Cited by 498 - Related articles - All 27 versions
Y Minokoshi, T Alquier, N Furukawa, YB Kim, A Lee, B … - Nature, 2004 - nature.com Obesity is an epidemic in Western society, and causes rapidly accelerating rates of type 2 diabetes
and cardiovascular disease. The evolutionarily conserved serine/threonine kinase, AMP-activated
protein kinase (AMPK), functions as a 'fuel gauge' to monitor cellular energy status 1 . We ... Cited by 491 - Related articles - BL Direct - All 9 versions
RD Cone - Nature neuroscience, 2005 - dept.wofford.edu The central melanocortin system is perhaps the best-characterized neuronal pathway involved
in the regulation of energy homeostasis. This collection of circuits is unique in having the capability
of sensing signals from a staggering array of hormones, nutrients and afferent neural ... Cited by 288 - Related articles - All 9 versions
GJ Morton, DE Cummings, DG Baskin, GS Barsh, MW … - NATURE-LONDON-, 2006 - chc.ucsf.edu The capacity to adjust food intake in response to changing energy requirements is essential
for survival. Recent progress has provided an insight into the molecular, cellular and behavioural
mechanisms that link changes of body fat stores to adaptive adjustments of feeding ... Cited by 274 - Related articles - View as HTML - BL Direct - All 11 versions
- ►kosen21.org [PDF] MW Schwartz, D Porte Jr - Science, 2005 - sciencemag.org Recent evidence suggests a key role for the brain in the control of both body fat content and glucose
metabolism. Neuronal systems that regulate energy intake, energy expenditure, and endogenous
glucose production sense and respond to input from hormonal and nutrient-related ... Cited by 268 - Related articles - All 12 versions
S Obici, BB Zhang, G Karkanias, L Rossetti - Nature medicine, 2002 - nature.com Circulating insulin inhibits endogenous glucose production. Here we report that bidirectional
changes in hypothalamic insulin signaling affect glucose production. The infusion of either insulin
or a small-molecule insulin mimetic in the third cerebral ventricle suppressed glucose ... Cited by 225 - Related articles - BL Direct - All 4 versions
M Merkel, RH Eckel, IJ Goldberg… - The Journal of Lipid Research, 2002 - ASBMB Page 1. 1 Lipoprotein lipase: genetics, lipid uptake and regulation Martin Merkel 1 , Robert
H. Eckel 2 , Ira J. Goldberg 3 1 Department of Medicine, University of Hamburg 2 Department
of Medicine, University of Colorado Health Sciences Center ... Cited by 212 - Related articles - BL Direct - All 4 versions
S Obici, Z Feng, A Arduini, R Conti, L Rossetti - Nature medicine, 2003 - nature.com The enzyme carnitine palmitoyltransferase-1 (CPT1) regulates long-chain fatty acid (LCFA) entry
into mitochondria, where the LCFAs undergo -oxidation. To investigate the mechanism(s) by
which central metabolism of lipids can modulate energy balance, we selectively reduced ... Cited by 200 - Related articles - BL Direct - All 6 versions
MS Kim, JY Park, C Namkoong, PG Jang, JW Ryu, … - Nature medicine, 2004 - bachpharma.com 1Department of Internal Medicine and 2Asan Institute for Life Sciences, University of Ulsan College
of Medicine, 138-736 Poongnap-dong, Songpa-ku, Seoul 138- 736, Korea. 3Department of Molecular
Biology, Kyunghee University College of Medicine, 1 Hoegi-dong Tongdaemun-gu, Seoul ... Cited by 170 - Related articles - BL Direct - All 9 versions
A Pocai, TKT Lam, R Gutierrez-Juarez, S Obici, GJ … - Nature, 2005 - nature.com Obesity is the driving force behind the worldwide increase in the prevalence of type 2 diabetes
mellitus 1, 2 . Hyperglycaemia is a hallmark of diabetes and is largely due to increased hepatic
gluconeogenesis 3 . The medial hypothalamus is a major integrator of nutritional and ... Cited by 154 - Related articles - All 7 versions
