- ►cell.com BB Kahn, T Alquier, D Carling, DG Hardie - Cell metabolism, 2005 - Elsevier The AMP-activated protein kinase (AMPK) is an evolutionarily conserved sensor of cellular energy
status, and recent data demonstrate that it also plays a critical role in systemic energy
balance. AMPK integrates nutritional and hormonal signals in peripheral tissues and the ... Cited by 648 - Related articles - All 11 versions
- ►daegu.ac.kr [PDF] D Carling - Trends in biochemical sciences, 2004 - Elsevier AMP-activated protein kinase (AMPK) is the downstream component of a protein kinase cascade
that acts as an intracellular energy sensor maintaining the energy balance within the cell. This
pivotal role of AMPK places it in an ideal position for regulating whole-body energy ... Cited by 376 - Related articles - All 12 versions
DG Hardie, JW Scott, DA Pan, ER Hudson - FEBS letters, 2003 - Elsevier The AMP-activated protein kinase is a sensor of cellular energy status that is found in all eukaryotic
cells. It is activated by rising AMP and falling ATP by a complex mechanism that results in an
ultrasensitive response. The functions of the different domains on the three subunits of the ... Cited by 268 - Related articles - All 11 versions
- ►nih.gov B Viollet, F Andreelli, SB Jørgensen, C … - Journal of Clinical …, 2003 - Am Soc Clin Investig AMP-activated protein kinase (AMPK) is viewed as a fuel sensor for glucose and lipid
metabolism. To better understand the physiological role of AMPK, we generated a knockout mouse
model in which the AMPKα2 catalytic subunit gene was inactivated. AMPKα2 –/– mice ... Cited by 207 - Related articles - BL Direct - All 11 versions
- ►nih.gov RR Russell III, J Li, DL Coven, M Pypaert, … - Journal of Clinical …, 2004 - Am Soc Clin Investig AMP-activated protein kinase (AMPK) is an important regulator of diverse cellular pathways in
the setting of energetic stress. Whether AMPK plays a critical role in the metabolic and functional
responses to myocardial ischemia and reperfusion remains uncertain. We examined the ... Cited by 199 - Related articles - BL Direct - All 9 versions
SB Jørgensen, B Viollet, F Andreelli, C Frøsig, JB … - Journal of Biological …, 2004 - ASBMB We investigated the importance of the two catalytic α-isoforms of the 5′-AMP-activated protein
kinase (AMPK) in 5-aminoimidazole-4-carboxamide-1-β-4-ribofuranoside (AICAR) and
contraction-induced glucose uptake in skeletal muscle. Incubated soleus and EDL ... Cited by 190 - Related articles - BL Direct - All 4 versions
- ►cell.com G Polekhina, A Gupta, BJ Michell, B van Denderen, S … - Current Biology, 2003 - Elsevier AMP-activated protein kinase (AMPK) is a multisubstrate enzyme activated by increases in AMP
during metabolic stress caused by exercise, hypoxia, lack of cell nutrients [1], as well as
hormones, including adiponectin and leptin [2] and [3]. Furthermore, metformin and ... Cited by 182 - Related articles - All 13 versions
- ►physiology.org K Sakamoto, LJ Goodyear - Journal of Applied Physiology, 2002 - Am Physiological Soc Physical exercise is a significant stimulus for the regulation of multiple metabolic and transcriptional
processes in skeletal muscle. For example, exercise increases skeletal muscle glucose
uptake, and, after exercise, there are increases in the rates of both glucose uptake and ... Cited by 152 - Related articles - BL Direct - All 3 versions
GA Rutter, GDS Xavier, I Leclerc - Biochemical Journal, 2003 - pubmedcentral.nih.gov AMPK (5 -AMP-activated protein kinase) is emerging as a meta- bolic master switch, by which
cells in both mammals and lower organisms sense and decode changes in energy status. Changes
in AMPK activity have been shown to regulate glucose transport in muscle and glucose ... Cited by 141 - Related articles - BL Direct - All 8 versions
D Carling - Biochimie, 2005 - Elsevier AMP-activated protein kinase (AMPK) is the central component of a protein kinase cascade that
plays a key role in the regulation of energy control. AMPK is activated in response to an increase
in the ratio of AMP:ATP within the cell. Activation requires phosphorylation of threonine ... Cited by 103 - Related articles - All 4 versions
