C Tiraby, G Tavernier, C Lefort, D Larrouy, F … - Journal of Biological …, 2003 - ASBMB Obesity, ie an excess of white adipose tissue (WAT), predisposes to the development of type
2 diabetes and cardiovascular disease. Brown adipose tissue is present in rodents but not in
adult humans. It expresses uncoupling protein 1 (UCP1) that allows dissipation of energy ... Cited by 171 - Related articles - BL Direct - All 5 versions
- ►jlr.org FB Kraemer, WJ Shen - The Journal of Lipid Research, 2002 - ASBMB Hormone-sensitive lipase (HSL) is an intracellular neutral lipase that is capable of hydrolyzing
triacylglycerols, diacylglycerols, monoacylglycerols, and cholesteryl esters, as well as other lipid
and water soluble substrates. HSL activity is regulated post-translationally by ... Cited by 116 - Related articles - BL Direct - All 5 versions
SJ Yeaman - Biochemical Journal, 2004 - pubmedcentral.nih.gov Although described initially as an intracellular adipocyte-specific triacylglycerol lipase, it is now
clear that HSL (hormone-sensitive lipase) is expressed in multiple tissues and plays a number
of roles in lipid metabolism, including that of a neutral cholesteryl ester hydrolase. The ... Cited by 99 - Related articles - BL Direct - All 8 versions
- ►alfediam.org [PDF] V Large, O Peroni, D Letexier, H Ray, M Beylot - Diabetes and Metabolism, 2004 - Elsevier Adipose tissue is considered as the body's largest storage organ for energy in the form of
triacylglycerols, which are mobilized through lipolysis process, to provide fuel to other organs
and to deliver substrates to liver for gluconeogenesis (glycerol) and lipoprotein synthesis ( ... Cited by 72 - Related articles - All 4 versions
- ►jbc.org L O'Rourke, LM Gronning, SJ Yeaman, PR … - Journal of Biological …, 2002 - ASBMB Insulin resistance, obesity, and diabetes are characterized by hyperglycemia,
hyperinsulinemia, and hyperleptinemia and are associated with increased risk of
atherosclerosis. In an effort to understand how this occurs, we have investigated whether ... Cited by 67 - Related articles - BL Direct - All 6 versions
- ►unimaas.nl [PDF] N Viguerie, H Vidal, P Arner, C Holst, C Verdich, S … - Diabetologia, 2005 - Springer Abstract Aims/hypothesis: Adaptation to energy restric- tion is associated with changes in gene
expression in adipose tissue. However, it is unknown to what extent these changes are dependent
on the energy restriction as such or on the macronutrient composition of the diet. ... Cited by 59 - Related articles - All 9 versions
- ►physiology.org JY Kim, K Tillison, JH Lee, DA Rearick, … - American Journal of …, 2006 - Am Physiological Soc The minimal adipose phenotype of hormone-sensitive lipase (HSL)-null mice suggested that
other hormonally responsive lipase(s) were present in adipocytes. Recent studies have characterized
a new adipose tissue triglyceride lipase, ATGL/PNPLA2/destnutrin/iPLA2 /TTS2.2 (ATGL). ... Cited by 42 - Related articles - BL Direct - All 4 versions
- ►pubget.com [PDF] H Coon, Y Xin, PN Hopkins, RM Cawthon, SJ Hasstedt, … - Human genetics, 2005 - Springer Abstract Positive evidence has been reported for linkage and association between the upstream
stimulatory factor 1 gene (USF1) and familial combined hyperlipidemia (FCHL). We genotyped
the two most positive single- nucleotide polymorphisms (SNPs) (usf1s1: rs3737787 and ... Cited by 42 - Related articles - BL Direct - All 6 versions
- ►oxfordjournals.org W Putt, J Palmen, V Nicaud, DA Tregouet, N … - Human Molecular …, 2004 - Oxford Univ Press Upstream stimulatory factor 1 (USF 1), is a transcription factor controlling expression of several
genes involved in lipid and glucose homeostasis and co-localizes with familial combined hyperlipidemia
(FCHL) and type 2 diabetes on chromosome 1q22–23. We sequenced USF1 in 24 UK ... Cited by 41 - Related articles - BL Direct - All 9 versions
C Asensio, P Cettour-Rose, C Theander-Carrillo, F … - Endocrinology, 2004 - Endocrine Soc Resistin is an adipose-derived hormone that has been proposed as a link among obesity, insulin
resistance, and diabetes. In agreement with a role of resistin in insulin resistance, the administration
of recombinant resistin led to glucose intolerance in mice and impaired insulin action in ... Cited by 37 - Related articles - BL Direct - All 4 versions
