- ►rupress.org U Grohmann, F Fallarino, R Bianchi, C … - Journal of Experimental …, 2003 - jem.rupress.org The predisposition of nonobese diabetic (NOD) mice to develop autoimmunity reflects deficiencies
in both peripheral and central tolerance. Several defects have been described in these mice,
among which aberrant antigen-presenting cell function and peroxynitrite formation. ... Cited by 87 - Related articles - BL Direct - All 8 versions
MR Hayden, SC Tyagi - Cardiovascular Diabetology, 2002 - cardiab.com Metabolic syndrome, insulin resistance, prediabetes, and overt type 2 diabetes mellitus are associated
with an accelerated atherosclerosis (atheroscleropathy). This quartet is also associated with
multiple metabolic toxicities resulting in the production of reactive oxygen species. The ... Cited by 57 - Related articles - Cached - All 14 versions
MR Hayden, SC Tyagi - JOP. J Pancreas (Online), 2002 - joplink.net Conclusions Redox sensitive cellular signaling systems play an important role in the
development, progressive nature (remodeling) and damaging effects on the beta cell within the
islet of the pancreas. Furthermore, redox stress may play an important role in the ... Cited by 48 - Related articles - Cached - All 5 versions
- ►duke.edu [PDF] M de Groot, TA Schuurs, R van Schilfgaarde - Journal of Surgical Research, 2004 - Elsevier Successful transplantation of pancreatic tissue has been demonstrated to be an efficacious method
of restoring glycemic control in type 1 diabetic patients. To establish graft acceptance patients
require lifelong immunosuppression, which in turn is associated with severe deleterious ... Cited by 46 - Related articles - All 11 versions
- ►nih.gov [PDF] EC Lewis, L Shapiro, OJ Bowers, CA … - Proceedings of the …, 2005 - National Acad Sciences Islet transplantation for type 1 diabetic patients shows promising results with the use of nondiabetogenic
immunosuppressive therapy. However, in addition to compromising the immune system of transplant
recipients, long-term studies demonstrate that islet viability is impaired. Here, we ... Cited by 41 - Related articles - BL Direct - All 7 versions
T Matsuda, K Omori, T Vuong, M Pascual, … - American Journal of …, 2005 - interscience.wiley.com Nonspecific inflammation is associated with primary graft nonfunction (PNF). Inflammatory islet
damage is mediated at least partially by pro-inflammatory cytokines, such as interleukin-1β
(IL-1β) and tumor necrosis factor-α (TNF-α) produced by resident islet macrophages. The ... Cited by 40 - Related articles - All 4 versions
- ►jimmunol.org MMW Chong, Y Chen, R Darwiche, NL … - The Journal of …, 2004 - Am Assoc Immnol In type 1 diabetes, cytokine action on cells potentially contributes to cell destruction by direct
cytotoxicity, inducing Fas expression, and up-regulating class I MHC and chemokine expression
to increase immune recognition. To simultaneously block cell responsiveness to multiple ... Cited by 37 - Related articles - BL Direct - All 4 versions
SA Steer, AL Scarim, KT Chambers, JA … - PLoS Medicine, 2006 - medicine.plosjournals.org There are at least two phases of β-cell death during the development of autoimmune
diabetes: an initiation event that results in the release of β-cell-specific antigens, and a
second, antigen-driven event in which β-cell death is mediated by the actions of T ... Cited by 28 - Related articles - Cached - BL Direct - All 12 versions
- ►rupress.org Y Yasunami, S Kojo, H Kitamura, A Toyofuku, … - Journal of Experimental …, 2005 - jem.rupress.org Patients with insulin-dependent diabetes mellitus regularly fail to achieve insulin independence
after transplantation of islets from a single donor pancreas because of early graft loss (1, 2). Early
islet loss is estimated to occur in 50% of the transplanted islet mass (3) and occurs at ... Cited by 27 - Related articles - BL Direct - All 6 versions
- ►jimmunol.org J Allison, HE Thomas, T Catterall, TWH Kay, … - The Journal of …, 2005 - Am Assoc Immnol In type 1 diabetes, many effector mechanisms damage the cell, a key one being perforin/granzyme
B production by CD8 + T cells. The death receptor pathway has also been implicated in cell
death, and we have therefore generated NOD mice that express a dominant-negative ... Cited by 26 - Related articles - All 7 versions
