C Brodie, PM Blumberg - Apoptosis, 2003 - Springer The isoforms of the PKC family are activated in response to mitogenic stimuli, to inflammatory
stimuli, and to stress and play important roles in a variety of cellular functions including
apoptosis. PKCδ a member of the novel PKC subfamily, is actively involved in cell apop- ... Cited by 260 - Related articles - BL Direct - All 4 versions
MY Donath, J Størling, K Maedler, T Mandrup- … - Journal of Molecular …, 2003 - Springer Abstract Pancreatic islet β-cell death occurs in type 1 and 2 diabetes mellitus, leading to absolute
or relative insulin deficiency. β-cell death in type 1 diabetes is due predominantly to
autoimmunity. In type 2 diabetes β-cell death occurs as the combined consequence of ... Cited by 145 - Related articles - BL Direct - All 3 versions
T Mandrup-Poulsen - Biochemical pharmacology, 2003 - Elsevier Failure of insulin producing pancreatic β-cells is a common characteristic of type 1
(insulin-dependent) and type 2 (insulin non-dependent) diabetes mellitus. Accumulating evidence
suggests that programmed cell death (apoptosis) is the main form of β-cell death in these ... Cited by 71 - Related articles - All 5 versions
- ►diabetesjournals.org K Eitel, H Staiger, J Rieger, H Mischak, H Brandhorst, … - Diabetes, 2003 - Am Diabetes Assoc Insulin resistance as well as pancreatic ß-cell failure can be induced by elevated free fatty acid
(FFA) levels. We studied the mechanisms of FFA-induced apoptosis in rat and human
ß-cells. Chronic treatment with high physiological levels of saturated fatty acids (palmitate ... Cited by 60 - Related articles - BL Direct - All 4 versions
- ►endojournals.org R Riachy, B Vandewalle, J Kerr Conte, E Moerman, P … - Endocrinology, 2002 - Endocrine Soc Transplantation of islets of Langerhans is a potential cure for type 1 diabetes, but its success
is hampered by destruction of the islets. The data presented herein suggest that the active metabolite
of vitamin D 3 [1,25-(OH) 2 D 3 ] may promote islet cell survival by modulating the effects ... Cited by 48 - Related articles - BL Direct - All 5 versions
AG Kanthasamy, M Kitazawa, A Kanthasamy, … - … and Redox Signaling, 2003 - liebertonline.com INTRODUCTION O XIDATIVE STRESS AND APOPTOSIS contribute to the degen- erative processes
in many neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease,
Hunting- ton disease, and amyotrophic lateral sclerosis (10, 13, 18, 78, 79). Pathological ... Cited by 48 - Related articles - BL Direct - All 3 versions
R Bottino, P Lemarchand, M Trucco, N Giannoukakis - Gene Therapy, 2003 - nature.com Type 1 diabetes mellitus, an autoimmune disorder is an attractive candidate for gene and
cell-based therapy. From the use of gene-engineered immune cells to induce hyporesponsiveness
to autoantigens to islet and beta cell surrogate transplants expressing immunoregulatory ... Cited by 44 - Related articles - BL Direct - All 4 versions
ML Gross, E Ritz, A Schoof, M Adamczak, A Koch, … - Laboratory …, 2004 - nature.com The Streptozotocin (STZ) model of diabetes is commonly used for studies of diabetic nephropathy
although the histological lesions of the kidney are mild and do not resemble those seen in diabetic
patients. The SHR/N-cp rat model of type II diabetes spontaneously develops pronounced ... Cited by 41 - Related articles - BL Direct - All 3 versions
- ►ucla.edu [PDF] JJ MEIER, A BHUSHAN, PC BUTLER - Pediatric research, 2006 - journals.lww.com Both type 1 and type 2 diabetes are characterized by a marked deficit in beta-cell mass causing
insufficient insulin secretion. Beta-cell replacement strategies may eventually provide a cure
for diabetes. Current therapeutic approaches include pancreas and islet transplantation, ... Cited by 33 - Related articles - BL Direct - All 7 versions
IA Urusova, L Farilla, H Hui, E D'Amico, R Perfetti - Trends in Endocrinology & …, 2004 - Elsevier Apoptosis plays an important role in the normal physiology of the pancreas, the pathogenesis
of diabetes mellitus (DM) and the success rate of islet transplantation. Glucagon-like
peptide-1 (GLP-1), an incretin hormone with multiple effects on glucose metabolism and ... Cited by 32 - Related articles - All 10 versions
