- ►diabetesjournals.org R Bottino, AN Balamurugan, S Bertera, M … - Diabetes, 2002 - Am Diabetes Assoc The most commonly used technical approach to isolate human pancreatic islets
intended for allotransplants generates a product that is hampered by mechanical
and chemical insults, which dramatically reduce the mass of viable and ... Cited by 79 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org R Bottino, AN Balamurugan, H Tse, C … - Diabetes, 2004 - Am Diabetes Assoc The process of human islet isolation triggers a cascade of stressful events in
the islets of Langerhans involving activation of apoptosis and necrosis and the
production of proinflammatory molecules that negatively influence islet ... Cited by 72 - Related articles - BL Direct - All 4 versions
- ►jbc.org G Ferrer-Sueta, D Vitturi, I Batinic-Haberle, I … - Journal of Biological Chemistry, 2003 - ASBMB We have studied the reaction kinetics of ten manganese porphyrins, differing in
their meso substituents, with peroxynitrite (ONOO – ) and carbonate radical
anion ( ) using stopped-flow and pulse radiolysis, respectively. Rate ... Cited by 59 - Related articles - BL Direct - All 4 versions
T Mandrup-Poulsen - ANNALS-NEW YORK ACADEMY OF SCIENCES, 2003 - interscience.wiley.com Abstract: Type 1 diabetes is an immune-mediated disease critically dependent
upon the interaction between antigen-presenting cells and T cells. Clearly, both
CD4+ and CD8+ T cells are required, but activated CD4+ T cells are both ... Cited by 58 - Related articles - BL Direct - All 5 versions
- ►critcaremed.com LE Donnelly, DF Rogers - Drugs, 2003 - ingentaconnect.com Chronic obstructive pulmonary disease (COPD) is a common, smoking-relat-
Abstract ed, severe respiratory condition characterised by progressive,
irreversible airflow limitation. Current treatment of COPD is symptomatic, ... Cited by 49 - Related articles - BL Direct - All 10 versions
H Kaneto, N Katakami, D Kawamori, T … - Antioxidants & redox signaling, 2007 - liebertonline.com F AILURE OF PANCREATIC cells is the common characteris- tic of type 1 and type 2
diabetes. Type 1 diabetes melli- tus is induced by destruction of pancreatic
cells, which is mediated by an autoimmune mechanism and the consequent ... Cited by 48 - Related articles - BL Direct - All 4 versions
- ►daegu.ac.kr [PDF] E Kawasaki, N Abiru, K Eguchi - Diabetes research and clinical practice, 2004 - Elsevier The hallmark of immune-mediated type 1 diabetes is T cell-mediated destruction
of the insulin-producing β cells in the islets, which results from an imbalance
between disease promoting factors and protective elements. The precise ... Cited by 46 - Related articles - All 4 versions
R Bottino, P Lemarchand, M Trucco, N … - Gene Therapy, 2003 - nature.com Type 1 diabetes mellitus, an autoimmune disorder is an attractive candidate for
gene and cell-based therapy. From the use of gene-engineered immune cells to
induce hyporesponsiveness to autoantigens to islet and beta cell surrogate ... Cited by 44 - Related articles - BL Direct - All 4 versions
- ►rupress.org F Fallarino, R Bianchi, C Orabona, C Vacca, … - Journal of Experimental Medicine, 2004 - jem.rupress.org Prediabetes and diabetes in nonobese diabetic (NOD) mice have been targeted by a
variety of immunotherapies, including the use of a soluble form of cytotoxic T
lymphocyte antigen 4 (CTLA-4) and interferon (IFN)- . The cytokine, ... Cited by 45 - Related articles - BL Direct - All 5 versions
- ►columbia.edu [PDF] JW Yoon, HS Jun - American journal of therapeutics, 2005 - journals.lww.com Type 1 diabetes results from the destruction of insulin-producing pancreatic β
cells by a β cell-specific autoimmune process. β Cell autoantigens,
macrophages, dendritic cells, B lymphocytes, and T lymphocytes have been ... Cited by 44 - Related articles - BL Direct - All 4 versions
