AE Butler, J Jang, T Gurlo, MD Carty, WC Soeller, PC … - Diabetes, 2004 - Am Diabetes Assoc The islet in type 2 diabetes is characterized by a deficit in β-cell mass, increased β-cell
apoptosis, and impaired insulin secretion. Also, islets in type 2 diabetes often contain deposits
of islet amyloid derived from islet amyloid polypeptide (IAPP), a 37–amino acid protein ... Cited by 93 - Related articles - BL Direct - All 9 versions
TW Van Haeften, TB Twickler - European journal of clinical …, 2004 - igitur-archive.library.uu.nl Abstract Insulin-like growth factors (IGFs) have been implicated in normal growth, and especially
foetal pancreas beta-cell development. As low birth weight has been implicated in the development
of obesity and type 2 diabetes, much research has evolved into the importance of IGF and ... Cited by 31 - Related articles - View as HTML - BL Direct - All 11 versions
- ►endojournals.org LS Fetita, E Sobngwi, P Serradas, F Calvo, JF … - Journal of Clinical …, 2006 - Endocrine Soc Evidence synthesis: Human studies performed in children and adolescents suggest that offspring
who had been exposed to maternal diabetes during fetal life exhibit higher prevalence of impaired
glucose tolerance and markers of insulin resistance. Recent studies that directly ... Cited by 31 - Related articles - BL Direct - All 4 versions
G Sesti - Annals of Medicine, 2002 - Informa Pharma Science Pancreatic b-cell dysfunction and insulin resistance are two interrelated defects in the pathophysiology
of type 2 diabetes. Defects in peripheral insulin action precede the development of glucose
intolerance, as the pancreas compensates for insulin resistance by increasing insulin ... Cited by 27 - Related articles - BL Direct - All 9 versions
AI Duarte, MS Santos, R Seiça, CR Oliveira - Diabetes, 2004 - Am Diabetes Assoc Evidence suggests that oxidative stress is involved in the pathophysiology of diabetic complications
and that insulin has a neuroprotective role in oxidative stress conditions. In this study, we evaluated
the in vitro effect of insulin in the susceptibility to oxidative stress and in the transport of ... Cited by 12 - Related articles - BL Direct - All 4 versions
DJ Hill - Reviews in Endocrine & Metabolic Disorders, 2005 - Springer Insulin availability is a key factor in embryonic and fe- tal growth, and infants born with nesidioblastosis
or the Beckwith-Wiedemann syndrome, conditions associated with hyper-secretion of
insulin, exhibit enhanced fetal somatic growth. Conversely, transient neonatal diabetes or ... Cited by 14 - Related articles - BL Direct - All 3 versions
- ►endojournals.org M Martin, P Serradas, S Ramos, E Fernandez, L Goya, … - Endocrinology, 2005 - Endocrine Soc We have previously shown that fetuses from protein-caloric undernourished pregnant rats
(35% of control diet during the last week of pregnancy) at 21.5 d post coitum exhibit increased
ß-cell mass. This alteration is correlated with increased insulinemia and total pancreatic ... Cited by 11 - Related articles - All 5 versions
A Abodeely, GD Roye, DT Harrington, WG Cioffi - Surgery for Obesity and …, 2008 - Elsevier Obese women who become pregnant face many health risks, including gestational diabetes,
pregnancy-induced hypertension, and pre-eclampsia. These women also have a greater incidence
of preterm labor, cesarean sections, and perioperative morbidity. Infants born to obese ... Cited by 7 - Related articles - All 10 versions
K Momose, S Nunomiya, M Nakata, T Yada, M … - Medical Molecular …, 2006 - Springer Abstract The Goto–Kakizaki (GK) rat offers a genetic model of type 2 diabetes and displays profoundly
defective insulin secretion leading to basal hyperglycemia. This ani- mal is widely used for studying
type 2 diabetes. However, the morphological characteristics of the pancreatic islets of ... Cited by 7 - Related articles - BL Direct - All 3 versions
J Movassat, S Calderari, E Fernández, MA … - Diabetes Obes …, 2007 - interscience.wiley.com Now that reduction in β-cell mass has been clearly established in humans with type 2 diabetes
mellitus (T2D), the debate focuses on the possible mechanisms responsible for decreased
β-cell number. Appropriate inbred rodent models are essential tools for this purpose. The ... Cited by 7 - Related articles - All 2 versions
