- ►physiology.org G Jiang, BB Zhang - American Journal of Physiology- …, 2003 - Am Physiological Soc As a counterregulatory hormone for insulin, glucagon plays a critical role in maintaining glucose
homeostasis in vivo in both animals and humans. To increase blood glucose, glucagon promotes
hepatic glucose output by increasing glycogenolysis and gluconeogenesis and by ... Cited by 137 - Related articles - BL Direct - All 3 versions
- ►fasebj.org NA Taylor, VEN VAN DE, JM WIM, JWM CREEMERS - The FASEB Journal, 2003 - FASEB The proprotein convertases (PCs) are a seven-member family of endoproteases that activate
proproteins by cleavage at basic motifs. Expression patterns for individual PCs vary widely, and
all cells express several members. The list of substrates activated by PCs has grown to ... Cited by 127 - Related articles - BL Direct - All 4 versions
RW Gelling, XQ Du, DS Dichmann, J … - Proceedings of the …, 2003 - National Acad Sciences Glucagon, the counter-regulatory hormone to insulin, is secreted from pancreatic α cells in response
to low blood glucose. To examine the role of glucagon in glucose homeostasis, mice were generated
with a null mutation of the glucagon receptor (Gcgr −/− ). These mice display lower blood ... Cited by 80 - Related articles - BL Direct - All 7 versions
X Zhu, L Orci, R Carroll, C Norrbom, M … - Proceedings of the …, 2002 - National Acad Sciences The neuroendocrine processing endoproteases PC2 and PC1/3 are expressed in the β cells
of the islets of Langerhans and participate in the processing of proinsulin to insulin and
C-peptide. We have previously shown that disruption of PC2 (SPC2) expression ... Cited by 69 - Related articles - BL Direct - All 11 versions
- ►endojournals.org J Gromada, I Franklin, CB Wollheim - Endocrine reviews, 2007 - Endocrine Soc Glucagon, a hormone secreted from the -cells of the endocrine pancreas, is critical for blood
glucose homeostasis. It is the major counterpart to insulin and is released during hypoglycemia
to induce hepatic glucose output. The control of glucagon secretion is multifactorial and ... Cited by 61 - Related articles - BL Direct - All 4 versions
- ►nih.gov KW Sloop, JXC Cao, AM Siesky, HY Zhang … - Journal of Clinical …, 2004 - Am Soc Clin Investig Uncontrolled hepatic glucose production contributes significantly to hyperglycemia in patients
with type 2 diabetes. Hyperglucagonemia is implicated in the etiology of this condition;
however, effective therapies to block glucagon signaling and thereby regulate glucose ... Cited by 47 - Related articles - BL Direct - All 6 versions
R Kurukulasuriya, JT Link, DJ Madar, Z Pei, … - Current medicinal …, 2003 - ingentaconnect.com Abstract: A number of therapeutic targets are currently under investigation for inhibition of hepatic
glucose production with small molecules. Antagonists of the glucagon receptor, glycogen
phosphorylase, 11-β- hydroxysteroid dehydrogenase-1 and fructose 1,6-bisphosphatase ... Cited by 43 - Related articles - BL Direct - All 3 versions
- ►endojournals.org BE Dunning, JE Gerich - Endocrine reviews, 2007 - Endocrine Soc The hyperglycemic activity of pancreatic extracts was encountered some 80 yr ago during efforts
to optimize methods for the purification of insulin. The hyperglycemic substance was named
"glucagon," and it was subsequently determined that glucagon is a 29-amino acid peptide ... Cited by 32 - Related articles - BL Direct - All 5 versions
J Wang, Y Cao, DF Steiner - Journal of Biological Chemistry, 2003 - ASBMB Glucagon, the second major glucose-regulated hormone in the control of glucose
homeostasis, functions as a counter-regulator to insulin and is specifically produced by the pancreatic
α cells. Its excessive biosynthesis and secretion is associated with diabetes mellitus. The ... Cited by 26 - Related articles - BL Direct - All 5 versions
- ►endojournals.org M Vincent, Y Guz, M Rozenberg, G Webb, M Furuta, D … - Endocrinology, 2003 - Endocrine Soc To date, the role of pancreatic hormones in pancreatic islet growth and differentiation is poorly
understood. To address this issue, we examined mice with a disruption in the gene encoding
prohormone convertase 2 (PC2). These mice are unable to process proglucagon, ... Cited by 25 - Related articles - BL Direct - All 4 versions
