- ►aspetjournals.org KE Mayo, LJ Miller, D Bataille, S Dalle, B Goke, B … - Pharmacological reviews, 2003 - ASPET Peptide hormones within the secretin-glucagon family are expressed in endocrine cells of the
pancreas and gastrointestinal epithelium and in specialized neurons in the brain, and subserve
multiple biological functions, including regulation of growth, nutrient intake, and transit ... Cited by 143 - Related articles - BL Direct - All 7 versions
S Dalle, C Longuet, S Costes, C Broca, O Faruque, … - Journal of Biological …, 2004 - ASBMB By using the MIN6 cell line and pancreatic islets, we show that in the presence of a low glucose
concentration, corresponding to physiological glucagon release from cells, glucagon treatment
of the cell caused a rapid, time-dependent phosphorylation and activation of p44/p42 ... Cited by 34 - Related articles - BL Direct - All 3 versions
JL Estall, DJ Drucker - Current pharmaceutical design, 2006 - ingentaconnect.com Abstract: Glucagon and the glucagon-like peptides are derived from a common proglucagon
precursor, and regulate en- ergy homeostasis through interaction with a family of distinct G protein
coupled receptors. Three proglucagon-derived peptides, glucagon, GLP-1, and GLP-2, ... Cited by 26 - Related articles - BL Direct - All 5 versions
- ►endojournals.org C Longuet, C Broca, S Costes, EH Hani, D Bataille, S … - Endocrinology, 2005 - Endocrine Soc The p44/p42 MAPKs (ERK1/2) cascade regulates ß-cell nuclear events, which modulates cell
differentiation and gene transcription, whereas its implication in processes occurring in the
cytoplasm, such as activation of the exocytotic machinery, is still unclear. Using the MIN6 ... Cited by 18 - Related articles - All 7 versions
N Herbach, B Goeke, M Schneider, W Hermanns, E … - Regulatory peptides, 2005 - Elsevier This study aims to gain further insight into the effect of the expression of a dominant negative
GIPR on glucose homeostasis and postnatal development of the endocrine pancreas. The diabetic
phenotype of GIPR dn transgenic animals was first observed between 14 and 21 days of ... Cited by 11 - Related articles - All 3 versions
- ►iovs.org KA Vessey, DA Rushforth, WK Stell - Investigative ophthalmology & visual science, 2005 - ARVO METHODS. The effect of intravitreally injected peptides on the development of form-deprivation
(FD) myopia and on the growth of eyes with unrestricted vision was determined by refraction
and A-scan ultrasonography. Chicks received three injections, one every 48 hours, of ... Cited by 11 - Related articles - BL Direct - All 3 versions
- ►endojournals.org G Fontes, AD Lajoix, F Bergeron, S Cadel, A Prat, T … - Endocrinology, 2005 - Endocrine Soc Miniglucagon (MG), the C-terminal glucagon fragment, processed from glucagon by the
MG-generating endopeptidase (MGE) at the Arg 17 –Arg 18 dibasic site, displays biological effects
opposite to that of the mother-hormone. This secondary processing occurs in the ... Cited by 9 - Related articles - All 6 versions
- ►endojournals.org A Dey, GM Lipkind, Y Rouille, C Norrbom, J Stein, C … - Endocrinology, 2005 - Endocrine Soc To define the biological significance of the initial cleavage at the proglucagon (PG) interdomain
site, K70-R71 , we created two interdomain mutants, K70Q-R71Q and R71A. Cotransfection
studies in GH4C1 cells show significant amounts of glucagon production by PC2 along ... Cited by 9 - Related articles - All 5 versions
D Bataille - Journal of Molecular Medicine, 2007 - Springer Abstract Many peptide hormones implicated in the regu- lation of intermediary metabolism arise
from larger pre- cursors called prohormones. These precursors are cut into pieces by proprotein
convertases, more precisely those called prohormone convertases (PCs) that cleave at ... Cited by 7 - Related articles - BL Direct - All 5 versions
- ►endojournals.org F Authier, PH Cameron, C Merlen, M Kouach, G Briand - Endocrinology, 2003 - Endocrine Soc We have investigated the proteolytic mechanisms of glucagon degradation within hepatic endosomes
at neutral pH before lumen acidification. Hepatic endosomes incubated at neutral pH rapidly
degraded native glucagon into 13 intermediate products, one of which corresponded to ... Cited by 7 - Related articles - BL Direct - All 4 versions
